Anti-Human ITGAV Therapeutic Antibody (Abituzumab) (CAT#: TAB-H01)

Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.

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Block

Figure 1 Abituzumab Blocks Elevated Expression of FMT-Related Genes in H358-Fibroblast Co-cultures.

Block

Figure 2 Inhibition of Abituzumab to FMT-Related genes expression in H358-Fibroblast co-cultures.

Inhib

Figure 3 Inhibition of ανβ6 6 binding to LAP by Abituzumab in comparison to anti-HEL-AB MSB0011523H-1 and 10D5, respectively

Agonist

Figure 4 DI17E6 promotes detachment of prostate cancer cells from vitronectin.

Prostate cancer cell lines (LNCaP, C4-2B, ARCaP, PC3, DU145 and VCaP cells) were seeded on 96-well plates coated with vitronectin.

Jiang, Y. , Dai, J. , Yao, Z. , Shelley, G. , & Keller, E. T. . (2017). Abituzumab targeting of αv-class integrins inhibits prostate cancer progression. molecular cancer research mcr, 15(7), molcanres.0447.2016.

Inhib

Figure 5 DI17E6 inhibits adhesion of prostate cancer cells on vitronectin.

Prostate cancer cell lines (LNCaP, C4-2B, ARCaP, PC3, DU145 and VCaP cells) were seeded on the 96-well plates pre-coated with fibronectin.

Jiang, Y. , Dai, J. , Yao, Z. , Shelley, G. , & Keller, E. T. . (2017). Abituzumab targeting of αv-class integrins inhibits prostate cancer progression. molecular cancer research mcr, 15(7), molcanres.0447.2016.


Specifications

  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG2 - kappa
  • Specificity
  • ITGAV (integrin alpha V, CD51) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • Inhib, Agonist
  • CAS
  • 1105038-73-0
  • Generic Name
  • abituzumab
  • Related Disease
  • Colorectal cancers, metastatic

Applications

  • Application Notes
  • The Human ITGAV antibody has been reported in applications of Inhibition, Agonist.

Target

  • Alternative Names
  • abituzumab;1105038-73-0;EMD525797;EMD 525797;DI-17E6;DI17E6;ITGAV;integrin, alpha V;antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR;integrin alpha-

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Abituzumab.

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Afuco™ Anti-ITGAV ADCC Therapeutic Antibody (Abituzumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.

See other products for "ITGAV"


For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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