Anti-Human ITGAV Recombinant Antibody (Abituzumab) (CAT#: TAB-H01)

Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Datasheet
  • MSDS
  • COA
Block

Figure 1 Abituzumab Blocks Elevated Expression of FMT-Related Genes in H358-Fibroblast Co-cultures.

Block

Figure 2 Inhibition of Abituzumab to FMT-Related genes expression in H358-Fibroblast co-cultures.

Inhib

Figure 3 Inhibition of ανβ6 6 binding to LAP by Abituzumab in comparison to anti-HEL-AB MSB0011523H-1 and 10D5, respectively

Agonist

Figure 4 DI17E6 promotes detachment of prostate cancer cells from vitronectin.

Prostate cancer cell lines (LNCaP, C4-2B, ARCaP, PC3, DU145 and VCaP cells) were seeded on 96-well plates coated with vitronectin.

Jiang, Y. , Dai, J. , Yao, Z. , Shelley, G. , & Keller, E. T. . (2017). Abituzumab targeting of αv-class integrins inhibits prostate cancer progression. molecular cancer research mcr, 15(7), molcanres.0447.2016.

Inhib

Figure 5 DI17E6 inhibits adhesion of prostate cancer cells on vitronectin.

Prostate cancer cell lines (LNCaP, C4-2B, ARCaP, PC3, DU145 and VCaP cells) were seeded on the 96-well plates pre-coated with fibronectin.

Jiang, Y. , Dai, J. , Yao, Z. , Shelley, G. , & Keller, E. T. . (2017). Abituzumab targeting of αv-class integrins inhibits prostate cancer progression. molecular cancer research mcr, 15(7), molcanres.0447.2016.


Specifications

  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG2 - kappa
  • Specificity
  • ITGAV (integrin alpha V, CD51) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • Inhib, Agonist
  • CAS
  • 1105038-73-0
  • Generic Name
  • abituzumab
  • Related Disease
  • Colorectal cancers, metastatic

Applications

  • Application Notes
  • The Human ITGAV antibody has been reported in applications of Inhibition, Agonist.

Target

  • Alternative Names
  • abituzumab;1105038-73-0;EMD525797;EMD 525797;DI-17E6;DI17E6;ITGAV;integrin, alpha V;antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR;integrin alpha-

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Resources

  • Biosimilar Overview
Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Abituzumab.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Abituzumab"

Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.

See other products for "ITGAV"

Human Antibody

CAT Product Name Application Type
TAB-076 Anti-Human CD51 Recombinant Antibody (Intetumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Recombinant Antibody

CAT Product Name Application Type
PABL-250 Mouse Anti-ITGAV Recombinant Antibody (clone 17E6) WB, ELISA, FuncS Mouse IgG
MRO-0852-CN Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (CBACN-313) WB, FC Rabbit IgG
HPAB-1768-FY Human Anti-ITGAV Recombinant Antibody (clone 3F2) ELISA, FC, ADCC Humanized IgG
ZG-1065F Mouse Anti-ITGAV Recombinant Antibody (clone NKI-M7 (former AMF7)) ELISA, FC, IHC-Fr, IP Mouse IgG1
ZG-0775J Rabbit Anti-ITGAV Recombinant Antibody (clone 4G7) ELISA, IHC Rabbit IgG

scFv Fragment Antibody

CAT Product Name Application Type
PSBL-250 Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); scFv Fragment WB, ELISA, FuncS Mouse scFv
HPAB-1767-FY-F(E) Human Anti-ITGAV Recombinant Antibody (clone 12G3); scFv Fragment Cyt, ELISA Humanized scFv
HPAB-1768-FY-F(E) Human Anti-ITGAV Recombinant Antibody (clone 3F2); scFv Fragment Cyt, ELISA Humanized scFv

Fab Fragment Antibody

CAT Product Name Application Type
PFBL-250 Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); Fab Fragment WB, ELISA, FuncS Mouse Fab
HPAB-1767-FY-S(P) Human Anti-ITGAV Recombinant Antibody (clone 12G3); Fab Fragment Cyt, ELISA Humanized Fab
HPAB-1768-FY-S(P) Human Anti-ITGAV Recombinant Antibody (clone 3F2); Fab Fragment Cyt, ELISA Humanized Fab

Mouse Antibody

CAT Product Name Application Type
PABX-191-S (P) Recombinant Mouse Anti-αVβ3 Ectodomain Antibody scFv Fragment (17E6) Neut, FuncS scFv
PABX-191-F (E) Recombinant Mouse Anti-αVβ3 Ectodomain Antibody Fab Fragment (17E6) Neut, FuncS Fab

Blocking Antibody

CAT Product Name Application Type
NEUT-1537CQ Recombinant Mouse Anti-ITGAV Antibody (272-17E6) Inhib, ICC/IF, BL, FC, ELISA, IP IgG1
NEUT-1577CQ Recombinant Mouse Anti-ITGAV Antibody (13C2) FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion IgG1, κ
NEUT-1578CQ Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) FC, IF, ELISA, BL, IP IgG2a, κ
NEUT-1579CQ Recombinant Mouse Anti-ITGAV Antibody (10D5) IP, FC, BL IgG2a
NEUT-1580CQ Recombinant Mouse Anti-ITGAV Antibody (27.1) ICC/IF, FC, IP, IHC-Fr, BL IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1582CQ Recombinant Rat Anti-Itgav Antibody (RMV-7) FC, FuncS, IP, Neut IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1880 Hi-Affi™ Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (DS1880AB) WB, FC IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-076 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-H01 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
Thare are currently no Customer reviews or questions for TAB-H01. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

Send Inquiry

© 2022 Creative BioLabs. All Rights Reserved
  • 0
  • 0

Cart