Human Anti-IgE Recombinant Antibody (clone 47H4v5); Fab Fragment (CAT#: HPAB-AP105-YC-F(E))
Provided are anti-IgE antibodies that bind to the M1′ segment of a human IgE. The antibody can be used in treating and preventing IgE-mediated disorders, as well as kits comprising the anti-IgE antibodies.
Specific Inquiry
ADCC
-1.png)
Figure 1 shows the ability of humanized anti-IgE/M1′ antibody 47H4 v5 wt and afucosylted variant to induce ADCC.
While the wt and afuscosylated variants induce similar maximal cytotoxicity, the afucosylated variant ("AF") was more potent than the wildtype form (EC50 AF≈0.83 nM, EC50 wt≈6.6 nM).
-2.png)
Figure 2A-C show that serum IgE was reduced by 79%, and that IgE-producing plasma cells were reduced by 75%.
-3.png)
Figure 3E show no reduction in levels of other serum immunoglobulins.
Specifications
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human IgE
- Species Reactivity
- Human
- Clone
- 47H4v5
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for Antibody-Dependent Cellular Cytotoxicity Assay. For details, refer to Published Data.
Target
- Alternative Names
- Immunoglobulin E
Related Resources
Asthma
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 47H4v5"
See other products for "IgE"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (CMAB007) | ELISA | Humanized antibody |
| TAB-049ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (IGE009) | ELISA, Inhib, FC | Humanized antibody |
| TAB-034ZJ-F(E) | Anti-Human IgE Recombinant Antibody Fab Fragment (CMAB007) | ELISA | Humanized antibody |
| TAB-049ZJ-F(E) | Anti-Human IgE Recombinant Antibody Fab Fragment (IGE009) | ELISA, Inhib, FC | Humanized antibody |
| TAB-050ZJ-F(E) | Anti-Human IgE Recombinant Antibody Fab Fragment (IGE026) | ELISA, Inhib, FC | Humanized antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-095ZJ | Anti-Human IgE Therapeutic Single Domain Antibody (39D11) | ELISA, Inhib, FC | Single domain antibody |
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-009LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
| Gly-010LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
| Gly-011LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-009LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
| Gly-010LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
| Gly-011LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
| Gly-156LC | Recombinant Anti-Human IgE Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-156LC-1 | Recombinant Anti-Human IgE Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0209CQ-S(P) | Human Anti-IgE Recombinant Antibody (clone huTES-C21); scFv Fragment | ELISA, Block | Humanized scFv |
| HPAB-1572WJ-S(P) | Mouse Anti-IgE Recombinant Antibody; scFv Fragment (clone MAE13) | ELISA, WB, FC | Mouse scFv |
| HPAB-1573WJ-S(P) | Mouse Anti-IgE Recombinant Antibody; scFv Fragment (clone MAF15) | ELISA, WB, FC | Mouse scFv |
| HPAB-1574WJ-S(P) | Human Anti-IgE Recombinant Antibody; scFv Fragment (clone HuMAE11V1) | ELISA, WB, FC | Human scFv |
| HPAB-1600WJ-S(P) | Mouse Anti-IgE Recombinant Antibody; scFv Fragment (clone e426) | ELISA, WB | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0043-WJ-F(E) | Mouse Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0043-WJ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0519-WJ-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0519-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0520-WJ-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0520-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0521-WJ-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0521-WJ-F(E)) | ELISA | Human Fab |
| HPAB-AP674-YC-F(E) | Human Anti-IgE Recombinant Antibody (clone Omaizumab S267E/L328F); Fab Fragment | ELISA, FuncS | Humanized Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP102-YC | Mouse Anti-IgE Recombinant Antibody (clone 47H4) | ELISA | Mouse IgG |
| HPAB-AP103-YC | Mouse Anti-IgE Recombinant Antibody (clone 7A6) | WB, FuncS, ELISA | Mouse IgG |
| HPAB-AP104-YC | Mouse Anti-IgE Recombinant Antibody (clone 26A11) | ELISA | Mouse IgG |
| HPAB-AP105-YC | Human Anti-IgE Recombinant Antibody (clone 47H4v5) | ELISA | Human IgG |
| HPAB-1195-FY | Human Anti-IgE Recombinant Antibody (HPAB-1195-FY) | ELISA | Human IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-AP105-YC-F(E). Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.