Anti-IGF2 Antibody Prodrug, Protease Activated (m610.27)
CAT#: VS-1025-YC206
The Anti-IGF2 Antibody Prodrug, Protease Activated (m610.27) is an antibody prodrug comprised of a recombinant human antibody targeting human IGF2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IGF2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IGF2 effectively. IGF2 is a potent fetal growth factor that is often aberrantly re-expressed and overproduced in a wide variety of adult human cancers, including Wilms' tumor and hepatocellular carcinoma. It acts as a powerful oncogene by binding to the IGF1 Receptor (IGF1R) and promoting robust cell proliferation, cell survival, and protection against apoptosis. This overproduction frequently creates an autocrine or paracrine loop that sustains tumor growth and helps cancer cells resist therapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human IGF2
- Target
- IGF2
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- m610.27
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Growth Restriction, Severe, With Distinctive Facies and Silver-Russell Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include growth factor activity and insulin receptor binding
- Alternative Names
- IGF-II; Insulin Like Growth Factor 2; IGF2; GRDF
- Gene ID
- 3481
- UniProt ID
- P01344
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Related Diseases
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| HPAB-0613-WJ | Human Anti-IGF2 Recombinant Antibody (clone m610.27) | ELISA, Inhib | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0613-WJ-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); Fab Fragment | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0613-WJ-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-1733-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone M606); Fab Fragment | Inhib, WB, ELISA | Human Fab |
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| HPAB-1734-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610); Fab Fragment | Inhib, WB, ELISA | Human Fab |
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