Anti-Human IGF2 Recombinant Antibody (DX-2647) (CAT#: TAB-387CL)
Recombinant Human monoclonal antibody expressed in CHO binding to Human IGF2. This is a human monoclonal antibody against insulin-like growth factor-II that blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. DX-2647 inhibited IGF-II and, to a lesser extent, IGF-I-induced receptor tyrosine phosphorylation, cellular proliferation, and both anchorage-dependent and anchorage-independent colony formation in various cell lines. In addition, DX-2647 slowed tumor progression in the Hep3B xenograft model, causing decreased tumoral CD31 staining as well as reduced IGF-IIE and IGF-IR phosphorylation levels. Therefore, DX-2647 offers an alternative approach to targeting IGF-IR, blocking IGF-II signaling through both IGF-IR and IR-A.
Specific Inquiry
BL
Figure 1 DX-2647 blocks IGF-II–stimulated proliferation.
Representative plot of DX-2647–induced inhibition of IGF-II-stimulated and IGF-IIE (100 ng/mL)–stimulated Ba/F3 cell proliferation.
Dransfield, D. T., Cohen, E. H., Chang, Q., Sparrow, L. G., Bentley, J. D., Dolezal, O., ... & Phan, T. (2010). A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Molecular cancer therapeutics, 9(6), 1809-1819.
Inhib
Figure 2 DX-2647 inhibits anchorage-independent colony formation in HCC cell lines.
HepG2 cell anchorage-independent colony formation. Representative images of colonies are shown (inset).
Dransfield, D. T., Cohen, E. H., Chang, Q., Sparrow, L. G., Bentley, J. D., Dolezal, O., ... & Phan, T. (2010). A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Molecular cancer therapeutics, 9(6), 1809-1819.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- BL, Inhib
- Related Disease
- Cancer
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Applications
- Application Notes
- This antibody has been tested for use in Blocking and Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- IGF2; insulin-like growth factor 2; IGF-II; PP9974; C11orf43; insulin-like growth factor II; insulin-like growth factor type 2; insulin-like growth factor 2 (somatomedin A)
- Gene ID
- 3481
- UniProt ID
- P01344
Related Resources
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IGF2"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-740 | Anti-IGF2 Recombinant Antibody (Dusigitumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-231 | Human Anti-IGF2 Recombinant Antibody (clone DX-2647) | WB, ELISA, FuncS | Human IgG |
| MOB-2250MZ | Recombinant Mouse Anti-Human IGF2 Antibody (clone nBcdbn74305) | WB | Mouse antibody |
| MRO-0818-CN | Rabbit Anti-IGF2 Recombinant Antibody (clone CBACN-300) | WB, IF, IHC | Rabbit IgG |
| MOB-251YJL | Rabbit Anti-IGF2 Recombinant Antibody (clone CBI236) | ELISA | Rabbit IgG |
| VS3-QX582 | Mouse Anti-IGF2 Recombinant Antibody (clone 8H1) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-231 | Human Anti-IGF2 Recombinant Antibody (clone DX-2647); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0037LY-S(P) | Human Anti-IGF2 Recombinant Antibody; scFv Fragment (HPAB-0037LY-S(P)) | WB | Human scfv |
| HPAB-0613-WJ-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); scFv Fragment | ELISA, WB | Humanized scFv |
| HPAB-1733-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone M606); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1734-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610); scFv Fragment | Inhib, WB, ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-231 | Human Anti-IGF2 Recombinant Antibody (clone DX-2647); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0037LY-F(E) | Human Anti-IGF2 Recombinant Antibody; Fab Fragment (HPAB-0037LY-F(E)) | WB | Human Fab |
| HPAB-1733-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone M606); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1734-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1735-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m616); Fab Fragment | Inhib, WB, ELISA | Human Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1083CQ | Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1756 | Rabbit Anti-IGF2 Recombinant Antibody (clone DS1756AB) | ELISA | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-740 | Afuco™ Anti-IGF2 ADCC Recombinant Antibody (Dusigitumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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