Anti-Human IGF2 Recombinant Antibody (DX-2647)
CAT#: TAB-387CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human IGF2. This is a human monoclonal antibody against insulin-like growth factor-II that blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. DX-2647 inhibited IGF-II and, to a lesser extent, IGF-I-induced receptor tyrosine phosphorylation, cellular proliferation, and both anchorage-dependent and anchorage-independent colony formation in various cell lines. In addition, DX-2647 slowed tumor progression in the Hep3B xenograft model, causing decreased tumoral CD31 staining as well as reduced IGF-IIE and IGF-IR phosphorylation levels. Therefore, DX-2647 offers an alternative approach to targeting IGF-IR, blocking IGF-II signaling through both IGF-IR and IR-A.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- BL, Inhib
- Related Disease
- Cancer
Product Property
- Purity
- >95% (SDS-PAGE)
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Applications
- Application Notes
- This antibody has been tested for use in Blocking and Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
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Related Diseases
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-740 | Anti-IGF2 Recombinant Antibody (Dusigitumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-231 | Human Anti-IGF2 Recombinant Antibody scFv Fragment (PSBL-231) | WB, ELISA, FuncS | Human scFv |
| HPAB-0037LY-S(P) | Human Anti-IGF2 Recombinant Antibody; scFv Fragment (HPAB-0037LY-S(P)) | WB | Human scfv |
| HPAB-1733-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone M606); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1734-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1735-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m616); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-231 | Human Anti-IGF2 Recombinant Antibody Fab Fragment (PFBL-231) | WB, ELISA, FuncS | Human Fab |
| HPAB-0037LY-F(E) | Human Anti-IGF2 Recombinant Antibody; Fab Fragment (HPAB-0037LY-F(E)) | WB | Human Fab |
| HPAB-0613-WJ-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); Fab Fragment | ELISA, WB | Humanized Fab |
| HPAB-1733-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone M606); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1734-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1083CQ | Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1756 | Rabbit Anti-IGF2 Recombinant Antibody (clone DS1756AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-740 | Afuco™ Anti-IGF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-740) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1733-FY | Human Anti-IGF2 Recombinant Antibody (clone M606) | Inhib, WB, ELISA | Human IgG |
| HPAB-1734-FY | Human Anti-IGF2 Recombinant Antibody (clone m610) | Inhib, WB, ELISA | Human IgG |
| VS3-CJ258 | Mouse Anti-IGF2 Recombinant Antibody (clone PT1543) | IHC-P | Mouse IgG2b, κ |
| VS3-CJ259 | Mouse Anti-IGF2 Recombinant Antibody (clone ABT-IGF2) | IHC-P | Mouse IgG2b, κ |
| VS3-CJ260 | Mouse Anti-IGF2 Recombinant Antibody (VS3-CJ260) | IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC84 | Recombinant Anti-IGF2 Vesicular Antibody, EV Displayed (VS-0425-YC84) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3433 | Anti-IGF2 Immunohistochemistry Kit | IHC |
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