Recombinant Anti-IGF2 Vesicular Antibody, EV Displayed (VS-0425-YC84)
CAT#: VS-0425-YC84
The Recombinant Anti-IGF2 Vesicular Antibody, EV Displayed (VS-0425-YC84) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IGF2-expressed cells or tissues. The IGF2 is a growth factor from the insulin family, linked with conditions like Wilms tumor and Beckwith-Wiedemann syndrome.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IGF2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Insulin like growth factor 2
- Biological Process
- Carbohydrate metabolism, Glucose metabolism, Osteogenesis
- Molecular Function
- Growth factor, Hormone, Mitogen
- Cellular Localization
- Golgi apparatus
- Introduction
- This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
- Alternative Names
- C11orf43, FLJ44734, IGF-II
- Gene ID
- 3481
- UniProt ID
- P01344
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Related Diseases
Endocrine Resistance
Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-231 | Human Anti-IGF2 Recombinant Antibody Fab Fragment (PFBL-231) | WB, ELISA, FuncS | Human Fab |
| HPAB-0037LY-F(E) | Human Anti-IGF2 Recombinant Antibody; Fab Fragment (HPAB-0037LY-F(E)) | WB | Human Fab |
| HPAB-1733-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone M606); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1734-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1735-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m616); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2250MZ | Recombinant Mouse Anti-Human IGF2 Antibody (clone nBcdbn74305) | WB | Mouse antibody |
| HPAB-1733-FY | Human Anti-IGF2 Recombinant Antibody (clone M606) | Inhib, WB, ELISA | Human IgG |
| HPAB-1734-FY | Human Anti-IGF2 Recombinant Antibody (clone m610) | Inhib, WB, ELISA | Human IgG |
| ZG-0761J | Rabbit Anti-IGF2 Recombinant Antibody (clone 1D6) | ELISA | Rabbit IgG |
| VS3-FY735 | Recombinant Mouse Anti-IGF2 Antibody (clone 4F1-6D6-2D10) | IHC-P | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1083CQ | Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1756 | Rabbit Anti-IGF2 Recombinant Antibody (clone DS1756AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-740 | Afuco™ Anti-IGF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-740) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3433 | Anti-IGF2 Immunohistochemistry Kit | IHC |
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