IGF2

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For Research Use Only. Not For Clinical Use.


Background

IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Growth Restriction, Severe, With Distinctive Facies and Silver-Russell Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include growth factor activity and insulin receptor binding
IGF2
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, RAS pathway related proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts, Leydig cells, Syncytiotrophoblasts, Cytotrophoblasts, Peritubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)

Interaction

Interacts with MYORG; this interaction is required for IGF2 secretion (By similarity). Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling (PubMed:28873464).

Molecular function

Growth factor, Hormone, Mitogen

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