Anti-IGF2 Recombinant Antibody (Dusigitumab)
CAT#: TAB-740
Recombinant human monoclonal antibody expressed in CHO binding to human IGF2. Dusigitumab is a human monoclonal antibody designed for the treatment of cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG2
- Species Reactivity
- Human
- Applications
- Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, IHC and most other immunological methods.
- CAS
- 1204390-13-5
- Generic Name
- dusigitumab
- MW
- 151 kDa
- Related Disease
- Breast cancers
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
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Broad Application Utility
Dusigitumab is a fantastic antibody for IGF2 research. We have used it across a wide range of applications including ELISA, Flow Cytometry, and Immunoprecipitation. Its performance is consistent and reliable in every assay. The high purity determined by RP-HPLC gives us great confidence in our results.
Successful Neutralization Assay
We utilized this recombinant human monoclonal antibody for neutralization assays targeting human IGF2. It worked exceptionally well, inhibiting the ligand as expected. It is also suitable for Immunofluorescence and ICC, making it a versatile tool for studying cancer-related growth factors in a research setting.
Q&As
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What is Dusigitumab and what does it target?
A: Dusigitumab is a recombinant human monoclonal antibody (IgG2) that specifically binds to human IGF2 (Insulin-like Growth Factor 2). It is designed to inhibit the activity of IGF2 and is widely used in cancer research to study growth factor signaling pathways.
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Is this antibody suitable for functional assays?
A: Yes, this antibody is suitable for a wide variety of functional and immunological methods. It has been reported for use in Neutralization (Neut), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (FuncS), Flow Cytometry (FC), and Immunocytochemistry (ICC).
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Endocrine Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "dusigitumab"
Afuco™ Anti-IGF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-740)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human monoclonal antibody expressed in CHO binding to human IGF2. It is a human monoclonal antibody designed for the treatment of cancer.
DrugMonitor™ Anti-Dusigitumab Antibody (VS-1224-YC382)Dusigitumab is a human monoclonal antibody targeting IGF2, investigated in trials for cancer, advanced solid malignancies, unresectable or metastatic hepatocellular carcinoma (HCC), and hormone-sensitive, HER-2 negative metastatic breast cancer. The DrugMonitor™ Anti-Dusigitumab Antibody (VS-1224-YC382) is an anti-drug antibody (ADA) against Dusigitumab. This drug-based antibody is raised in mice immunized with the Dusigitumab. The anti-Dusigitumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Dusigitumab in samples.
See other products for "IGF2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-387CL | Anti-Human IGF2 Recombinant Antibody (DX-2647) | BL, Inhib | Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-231 | Human Anti-IGF2 Recombinant Antibody (PABL-231) | WB, ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-231 | Human Anti-IGF2 Recombinant Antibody scFv Fragment (PSBL-231) | WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-231 | Human Anti-IGF2 Recombinant Antibody Fab Fragment (PFBL-231) | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2250MZ | Recombinant Mouse Anti-Human IGF2 Antibody (clone nBcdbn74305) | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1083CQ | Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1756 | Rabbit Anti-IGF2 Recombinant Antibody (clone DS1756AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0037LY-S(P) | Human Anti-IGF2 Recombinant Antibody; scFv Fragment (HPAB-0037LY-S(P)) | WB | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0037LY-F(E) | Human Anti-IGF2 Recombinant Antibody; Fab Fragment (HPAB-0037LY-F(E)) | WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0818-CN | Rabbit Anti-IGF2 Recombinant Antibody (clone CBACN-300) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-740 | Afuco™ Anti-IGF2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-740) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0613-WJ | Human Anti-IGF2 Recombinant Antibody (clone m610.27) | ELISA, Inhib | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0613-WJ-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); Fab Fragment | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0613-WJ-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1733-FY | Human Anti-IGF2 Recombinant Antibody (clone M606) | Inhib, WB, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1733-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone M606); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1734-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1733-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone M606); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1734-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC84 | Recombinant Anti-IGF2 Vesicular Antibody, EV Displayed (VS-0425-YC84) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3433 | Anti-IGF2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC168 | SmartAb™ Recombinant Anti-IGF2 pH-dependent Antibody (Clone Dusigitumab) | Neut, ELISA, IF, IP, FC, ICC | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC206 | Anti-IGF2 Antibody Prodrug, Protease Activated (m610.27) | ISZ, Cyt, FuncS |
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