Anti-IL10 (clone BT-063) Recombinant Antibody Coupled Liposome (VS-1024-FY160) (CAT#: VS-1024-FY160)

• Potential Clinical Applications
• Leukaemia

• Clone
• BT-063

• Antibody Type
• IgG1

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This antibody is a recombinant human monoclonal antibody that was specifically designed to target interleukin-10 (IL-10), an important cytokine involved in immune regulation and inflammation. IL-10 plays a crucial role in modulating the immune response, promoting anti-inflammatory effects, and maintaining homeostasis within the immune system.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• IL10

• Introduction
• The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

• Alternative Names
• Interleukin 10

• Full Name
• Interleukin 10

• Gene ID
• 3586

• UniProt ID
• P22301

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn134 (NX_P22301 [NX_P22301-1])
  Glycosylation from GlyGen (P22301) 1 site

• Protein Refseq
• NP_001369553.1; NP_000563.1

• Function
• Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
  Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608).
  In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.

• HPAB-0224CQ
• Human Anti-IL10 Recombinant Antibody (clone BT-063)

• HPAB-0224CQ-F(E)
• Human Anti-IL10 Recombinant Antibody (clone BT-063); Fab Fragment

• HPAB-0224CQ-S(P)
• Human Anti-IL10 Recombinant Antibody (clone BT-063); scFv Fragment

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