Anti-IL10 (clone BT-063) Recombinant Antibody Coupled Liposome (VS-1024-FY160)
CAT#: VS-1024-FY160
Anti-IL-10 antibodies conjugated with liposomes are used to target the antitumor immune effects of IL-10 in leukemia. By blocking the action of IL-10, this treatment approach helps to restore tumor-specific immune responses and enhance the body's ability to eliminate tumor cells. Preclinical studies have shown that this targeted technology has the potential to improve therapeutic efficacy and reduce systemic side effects. Overall, anti-IL-10 antibody-conjugated liposomes provide a new direction for improving treatment strategies in leukemia patients.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71391/167603_B_9_5.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71391/167603_A_6_6.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (HMC-1, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136634-IL10
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More Infomation
Specifications
- Potential Clinical Applications
- Leukaemia
Product Composition
- Clone
- BT-063
- Antibody Type
- IgG1
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant human monoclonal antibody that was specifically designed to target interleukin-10 (IL-10), an important cytokine involved in immune regulation and inflammation. IL-10 plays a crucial role in modulating the immune response, promoting anti-inflammatory effects, and maintaining homeostasis within the immune system.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- IL10
- Introduction
- The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
- Alternative Names
- Interleukin 10
- Full Name
- Interleukin 10
- Gene ID
- 3586
- UniProt ID
- P22301
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn134 (NX_P22301 [NX_P22301-1])
Glycosylation from GlyGen (P22301) 1 site
- Protein Refseq
- NP_001369553.1; NP_000563.1
- Function
- Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608).
In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Systemic Lupus Erythematosus
Autoimmune Thyroid Disease
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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See other products for "Clone BT-063"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-080 | Rat Anti-IL10 Recombinant Antibody (clone 9D7); Fab Fragment | Neut | Rat Fab |
| HPAB-0022-YC-F(E) | Human Anti-IL10 Recombinant Antibody; Fab Fragment (HPAB-0022-YC-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0223CQ-F(E) | Mouse Anti-IL10 Recombinant Antibody (clone B-N10); Fab Fragment | ELISA, FC, Block | Mouse Fab |
| HPAB-0224CQ-F(E) | Human Anti-IL10 Recombinant Antibody (clone BT-063); Fab Fragment | ELISA, FC, Block | Humanized Fab |
| HPAB-0344-WJ-F(E) | Human Anti-IL10 Recombinant Antibody (clone 12G8); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-080 | Rat Anti-IL10 Recombinant Antibody (clone 9D7); scFv Fragment | Neut | Rat scFv |
| HPAB-0223CQ-S(P) | Mouse Anti-IL10 Recombinant Antibody (clone B-N10); scFv Fragment | ELISA, FC, Block | Mouse scFv |
| HPAB-0224CQ-S(P) | Human Anti-IL10 Recombinant Antibody (clone BT-063); scFv Fragment | ELISA, FC, Block | Humanized scFv |
| HPAB-0344-WJ-S(P) | Human Anti-IL10 Recombinant Antibody (clone 12G8); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0345-WJ-S(P) | Human Anti-IL10 Recombinant Antibody (clone 11D8); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0955CT | Recombinant Mouse anti-Human IL10 Monoclonal antibody (34849.22) | ELISA, Neut, WB | |
| HPAB-0022-YC | Human Anti-IL10 Recombinant Antibody (HPAB-0022-YC) | ELISA, Neut | Humanized IgG |
| HPAB-0223CQ | Mouse Anti-IL10 Recombinant Antibody (clone B-N10) | ELISA, FC, Block | Mouse IgG |
| HPAB-0224CQ | Human Anti-IL10 Recombinant Antibody (clone BT-063) | ELISA, FC, Block, FuncS | Humanized IgG |
| HPAB-0344-WJ | Human Anti-IL10 Recombinant Antibody (clone 12G8) | ELISA, WB | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0286MZ | Chicken Anti-Interleukin-10 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
| BRD-0585MZ | Chicken Anti-TGIF Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1098CQ | Mouse Anti-IL10 Recombinant Antibody (clone CBL397) | Neut, WB | Mouse IgG1 |
| NEUT-1099CQ | Mouse Anti-IL10 Recombinant Antibody (clone CBL549) | Neut, WB | Mouse IgG1 |
| NEUT-1100CQ | Mouse Anti-IL10 Recombinant Antibody (clone 23738.11) | ELISA, Neut, WB | Mouse IgG2b |
| NEUT-1101CQ | Mouse Anti-IL10 Recombinant Antibody (clone 6Q24) | Neut, WB | Mouse IgG2 |
| NEUT-1102CQ | Rat Anti-Il10 Recombinant Antibody (clone 15B9-1-2) | WB, ELISA, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1103CQ | Mouse Anti-IL10 Recombinant Antibody (clone B-S10) | Block | Mouse IgG1 |
| NEUT-1116CQ | Rat Anti-Il10 Recombinant Antibody (clone 2A5) | Block, ELISA, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1118CQ | Rat Anti-Il10 Recombinant Antibody (clone 5C69) | ELISA, Neut | Rat IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1786 | Rabbit Anti-IL10 Recombinant Antibody (clone DS1786AB) | WB | Rabbit IgG |
| MOR-4606 | Rabbit Anti-Il10 Recombinant Antibody (clone TH119DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0609LC | Rat Anti-IL10 Recombinant Antibody (clone 9D7) | ELISA | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3477 | Anti-IL10 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC162 | Recombinant Anti-IL10 Eliminating Antibody, pH-Sensitive (B-N10 var.) | Antigen-Sweeping In Vivo. | Mouse IgG |
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