Rabbit Anti-LDLR Recombinant Antibody (VS3-CJ236)
CAT#: VS3-CJ236
This product is a rabbit antibody that recognizes LDLR.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13159/29364_A_8_3_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranou
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_B_7_5.jpg
Normal Tissue
Figure 4 Stomach
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_A_6_1.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9647/25258_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13159/29364_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130164-LDLR
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse LDLR
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IHC, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Flow Cytometry.
Target
- Alternative Names
- FH; FHC; FHCL1; LDLCQ2
- Gene ID
- 3949
- UniProt ID
- P01130
- Sequence Similarities
- Belongs to the LDLR family.
- Cellular Localization
- Cell membrane, Coated pit, Endosome, Golgi apparatus, LDL
- Post Translation Modifications
- N- and O-glycosylated.
Ubiquitinated by MYLIP leading to degradation.
- Protein Refseq
- NP_000518.1; NP_001182727.1; NP_001182728.1
- Function
- Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins.
(Microbial infection) Acts as a receptor for Vesicular stomatitis virus.
(Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
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Related Diseases
Cushing Syndrome
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "LDLR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0029MZ | Recombinant Mouse Anti-Human LDLR Antibody (clone JgG-C8) | WB, FC, IF | Mouse antibody |
| MOB-0040MZ | Recombinant Mouse Anti-Human Lectin-like Oxidized LDL receptor-1 (sLOX-1) Soluble form Antibody (clone C019M) | ELISA | Mouse antibody |
| MRO-0922-CN | Recombinant Rabbit Anti-LDLR Monoclonal Antibody (CBACN-345) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-2011-CN | Rabbit Anti-LDLR Polyclonal Antibody (MRO-2011-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS11-QX101 | Mouse Anti-LDLR Recombinant Antibody (clone C7) | FC, IP, WB, Inhib, IF | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0323MZ | Chicken Anti-LDLR Polyclonal IgY | Anti-LDLR antibody produced in chicken is suitable for WBting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200. | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2033 | Hi-Affi™ Recombinant Rabbit Anti-LDLR Monoclonal Antibody (DS2033AB) | ICC, IF, WB, IP, FC, IHC-P | IgG |
| MOR-0086-FY | Rabbit Anti-LDLR Recombinant Antibody (clone AFY0057) | FC, ICC, IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-YC-S(P) | Mouse Anti-LDLR Recombinant Antibody (clone 12G4); scFv Fragment | ELISA, WB, IHC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0095-YC-F(E) | Mouse Anti-LDLR Recombinant Antibody (clone 12G4); Fab Fragment | ELISA, WB, IHC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC636 | Recombinant Anti-LDLR Vesicular Antibody, EV Displayed (VS-0425-YC636) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3975 | Anti-LDLR Immunohistochemistry Kit | IHC |
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