Rabbit Anti-MAPK3/MAPK1 Recombinant Antibody (VS3-FY2763) (CAT#: VS3-FY2763)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Mitogen-activated protein kinase 3 of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ICC, IP

• Conjugate
• Unconjugated, FITC

• Related Disease
• B-Cell Lymphoma and Pleural Mesothelioma

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunoprecipitation: 1/20
  Western Blot: 1/500-1/1000
  Immunocytochemistry: 1/50-1/200

• Alternative Names
• Mitogen-Activated Protein Kinase 3; Extracellular Signal-Regulated Kinase 1; Microtubule-Associated Protein 2 Kinase; Insulin-Stimulated MAP2 Kinase; MAP Kinase Isoform P44; EC 2.7.11.24; P44-ERK1; P44-MAPK; PRKM3; ERK-1; ERK1

• Gene ID
• 5595

• UniProt ID
• P27361

• Sequence Similarities
• Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

• Cellular Localization
• Cytoplasm
  Nucleus
  Membrane, caveola
  Cell junction, focal adhesion

• Post Translation Modifications
• Phosphorylated upon KIT and FLT3 signaling (By similarity).
  Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.
  Ligand-activated ALK induces tyrosine phosphorylation.
  Dephosphorylated by PTPRJ at Tyr-204.
  Ubiquitinated by TRIM15 via 'Lys-63'-linked ubiquitination; leading to activation.
  Deubiquitinated by CYLD.
  Ubiquitination at Lys317
  Modification sites at PhosphoSitePlus

• Protein Refseq
• NP_001035145.1; NP_001103361.1; NP_002737.2

• Function
• Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368).
  MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade.
  They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF.

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

• 2ND-057CQ
• Donkey Anti-Rabbit IgG (H&L) Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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