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    Rabbit Anti-MAPK3/MAPK1 Recombinant Antibody (VS3-FY2763) (CAT#: VS3-FY2763)

    The anti-MAPK3 antibody is specifically engineered to target human ERK1/2 protein. It shows capability of cross-reacting with mouse and rat. This monoclonal antibody proves valuable in disease research related to B-Cell Lymphoma and Pleural Mesothelioma.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2683/if_selected.jpg
    Normal Tissue
    Figure 2 Testis
    Figure 2 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5700/20815_A_5_6.jpg
    Figure 3 Breast
    Figure 3 Breast
    (Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5700/21384_B_3_4.jpg
    Figure 4 Lymph node
    Figure 4 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5700/20815_A_9_8.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5700/20815_A_9_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5700/20815_A_8_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/5700/20815_A_9_5.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102882-MAPK3

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Mitogen-activated protein kinase 3 of human, mouse and rat origins
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • WB, ICC, IP
    • Conjugate
    • Unconjugated, FITC
    • Related Disease
    • B-Cell Lymphoma and Pleural Mesothelioma

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Immunoprecipitation: 1/20
      Western Blot: 1/500-1/1000
      Immunocytochemistry: 1/50-1/200

    Target

    • Alternative Names
    • Mitogen-Activated Protein Kinase 3; Extracellular Signal-Regulated Kinase 1; Microtubule-Associated Protein 2 Kinase; Insulin-Stimulated MAP2 Kinase; MAP Kinase Isoform P44; EC 2.7.11.24; P44-ERK1; P44-MAPK; PRKM3; ERK-1; ERK1
    • Sequence Similarities
    • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    • Cellular Localization
    • Cytoplasm
      Nucleus
      Membrane, caveola
      Cell junction, focal adhesion
    • Post Translation Modifications
    • Phosphorylated upon KIT and FLT3 signaling (By similarity).
      Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme.
      Ligand-activated ALK induces tyrosine phosphorylation.
      Dephosphorylated by PTPRJ at Tyr-204.
      Ubiquitinated by TRIM15 via 'Lys-63'-linked ubiquitination; leading to activation.
      Deubiquitinated by CYLD.
      Ubiquitination at Lys317
      Modification sites at PhosphoSitePlus
    • Function
    • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368).
      MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade.
      They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Related Resources

    • Related Signaling Pathways
    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    CAT Product Name Application Type
    BRD-0342MZ Chicken Anti-MAPK3 Polyclonal IgY Indirect ELISA, WB Chicken antibody

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