Anti-MDM2 (clone W24V233) Recombinant Antibody Coupled Liposome (VS-1024-FY230) (CAT#: VS-1024-FY230)

• Potential Clinical Applications
• Pancreatic cancer

• Clone
• W24V233

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This innovative recombinant mouse monoclonal antibody has been specifically designed to interact with MDM2, a negative regulator of the p53 tumor suppressor. The ability of MDM2 to bind and inhibit p53 can lead to uncontrolled cell growth and tumor progression, thus targeting MDM2 represents a strategic avenue in cancer therapy. This antibody may help in restoring the activity of p53 in cancer cells, providing a means to suppress tumor development.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MDM2

• Introduction
• This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

• Alternative Names
• MDM2 Proto-Oncogene; MDM2 Proto-Oncogene, E3 Ubiquitin Protein Ligase; Oncoprotein Mdm2; Hdm2; Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse); Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein; Mouse Double Minute 2, Human Homolog Of; P53-Binding Protein; Double Minute 2, Human Homolog Of; P53-Binding Protein; Mdm2, P53 E3 Ubiquitin Protein Ligase Homolog; MDM2 Oncogene, E3 Ubiquitin Protein Ligase

• Full Name
• MDM2 Proto-Oncogene

• Gene ID
• 4193

• UniProt ID
• A7UKX8

• Sequence Similarities
• Belongs to the MDM2/MDM4 family.

• Cellular Localization
• Nucleus, nucleoplasm; Cytoplasm; Nucleus

• Post Translation Modifications
• Phosphorylation on Ser-166 by SGK1 activates ubiquitination of p53/TP53.
  Phosphorylated at multiple sites near the RING domain by ATM upon DNA damage; this prevents oligomerization and E3 ligase processivity and impedes constitutive p53/TP53 degradation.

• Protein Refseq
• XP_047284809.1; XP_054228034.1; XP_054228035.1; NP_001138809.1; NP_001138811.1

• Function
• E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:29681526).
  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
  Also acts as a ubiquitin ligase E3 toward itself and ARRB1.
  Permits the nuclear export of p53/TP53.

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