Rabbit Anti-MPL Recombinant Antibody (clone R03-1C9)
CAT#: VS3-FY1910
This R03-1C9 recombinant monoclonal antibody was developed to recognize human MPL. It cross-reacts with mouse, rat. The binding specificity of the thrombopoietin receptor antibody was determined using western blot analysis of TPOR/MPL in K562, C6 lysates.
Gene Expression
Tested Data
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7619/1825_E1_28_cr5abb7d728bca3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117400-MPL
❮
❯
WB
Figure 1 Anti-MPL Antibody (VS3-FY1910) in WB.
The TPOR/MPL expression in K562, C6 lysates were detected using the anti-Thrombopoietin Receptor by western blot assay.
❮
❯
Specifications
- Immunogen
- Synthetic peptide of human TPOR
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat MPL
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R03-1C9
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 71 kDa, while the observed molecular weight stands at 85 kDa.
- Related Disease
- Cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- MPL Proto-Oncogene, Thrombopoietin Receptor; Myeloproliferative Leukemia Virus Oncogene; Myeloproliferative Leukemia Protein; Proto-Oncogene C-Mpl; TPO-R; TPOR; Thrombopoietin Receptor
- Gene ID
- 4352
- UniProt ID
- P40238
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 1 subfamily.
- Cellular Localization
- Cell membrane, Golgi apparatus, Membrane
- Post Translation Modifications
- Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways.
The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
- Protein Refseq
- NP_005364.1
- Function
- Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-FY1910. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MPL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-155CQ | Human Anti-MPL Recombinant Antibody (TAB-155CQ) | ELISA, FC, FuncS | Human IgG1 |
| TAB-155CQ-S(P) | Human Anti-MPL Recombinant Antibody; scFv Fragment (TAB-155CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-155CQ-F(E) | Human Anti-MPL Recombinant Antibody; Fab Fragment (TAB-155CQ-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156CQ | Anti-Human MPL Recombinant Antibody (TA136) | ELISA, FC | |
| TAB-157CQ | Anti-Human MPL Recombinant Antibody (VB22B) | ELISA, FC | |
| TAB-156CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (TA136) | ELISA, FC | |
| TAB-157CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (VB22B) | ELISA, FC | |
| TAB-156CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (TA136) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2272 | Hi-Affi™ Recombinant Rabbit Anti-MPL Monoclonal Antibody (DS2272AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-108LC | Recombinant Human Anti-Human MPL Agonist Antibody (12B5) | FC, FunS, ELISA | Human antibody |
| MOB-109LC | Recombinant Human Anti-Human MPL Agonist Antibody (12D5) | FC, FunS, ELISA | Human antibody |
| MOB-110LC | Recombinant Human Anti-Human MPL Agonist Antibody (12E10) | FC, FunS, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0566-CN) | ELISA, FC, Block | Mouse IgG2b, κ |
| HPAB-0567-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0567-CN) | ELISA, FC, Block | Mouse IgG2b, κ |
| HPAB-0568-CN | Mouse Anti-MPL Recombinant Antibody (HPAB-0568-CN) | ELISA, FC, Block | Mouse IgG1, κ |
| HPAB-0411-YC | Mouse Anti-MPL Recombinant Antibody (HPAB-0411-YC) | FC, ELISA | Mouse IgG1, κ |
| HPAB-0412-YC | Human Anti-MPL Recombinant Antibody (HPAB-0412-YC) | FC, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0566-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0567-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0567-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0568-CN-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0568-CN-S(P)) | ELISA, FC, Block | Mouse scFv |
| HPAB-0411-YC-S(P) | Mouse Anti-MPL Recombinant Antibody; scFv Fragment (HPAB-0411-YC-S(P)) | FC, ELISA | Mouse scFv |
| HPAB-0412-YC-S(P) | Human Anti-MPL Recombinant Antibody scFv Fragment (HPAB-0412-YC-S(P)) | FC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0566-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0567-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0567-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0568-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0568-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0411-YC-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0411-YC-F(E)) | FC, ELISA | Mouse Fab |
| HPAB-0412-YC-F(E) | Human Anti-MPL Recombinant Antibody Fab Fragment (HPAB-0412-YC-F(E)) | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY143 | Human Anti-MPL (clone 5E5) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC552 | Recombinant Anti-MPL Vesicular Antibody, EV Displayed (VS-0425-YC552) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC127 | Recombinant Anti-MPL (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | Block, ELISA, FC | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
-3.png)
Application: ELISA, FC, Block, SPR
Application: ELISA, FuncS, Neut, IF, WB, EM, Inhib, IHC
Application: ELISA, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
