This product is a recombinant mouse antibody that recognizes NOTCH2. The antibody was purified by affinity chromatography. It can be used in ELISA, IHC.
Figure 1 Specificity of anti-Notch1 and anti-Notch 2 blocking antibodies.
ELISA experiments were carried out with serial dilutions of antibodies on immobilised NRR domains ofmouse Notch1.
Falk, R., Falk, A., Dyson, M. R., Melidoni, A. N., Parthiban, K., Young, J. L., ... & McCafferty, J. (2012). Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods, 58(1), 69-78.
Figure 2 Cell based assays for identification of blocking antibodies to Notch1 and2.
Six sequence unique anti-NRR1 antibodies were identified to efficiently block activation in HEK-Notch1 cells compared to an unrelated control antibody.
Falk, R., Falk, A., Dyson, M. R., Melidoni, A. N., Parthiban, K., Young, J. L., ... & McCafferty, J. (2012). Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods, 58(1), 69-78.
Figure 3 Receptor specific and dose dependent inhibition of Notch signalling between cells.
Dose response curves were generated by titration of N1_E6 on HEK-Notch1 andantibodies N2_B6 and N2_B9 on HEK-Notch2.
Falk, R., Falk, A., Dyson, M. R., Melidoni, A. N., Parthiban, K., Young, J. L., ... & McCafferty, J. (2012). Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods, 58(1), 69-78.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2555z | Mouse Anti-NOTCH2 Recombinant Antibody (clone 19B5) | ELISA, IHC | Mouse IgG1, κ |
HPAB-0038-CN | Human Anti-NOTCH2 Recombinant Antibody (HPAB-0038-CN) | FC, ELISA | Human IgG2, κ |
HPAB-0039-CN | Human Anti-NOTCH2 Recombinant Antibody (HPAB-0039-CN) | FC, ELISA | Human IgG2, κ |
HPAB-0595-WJ | Human Anti-NOTCH2 Recombinant Antibody (clone D) | ELISA, WB | Human IgG |
HPAB-0596-WJ | Human Anti-NOTCH2 Recombinant Antibody (clone D-1) | ELISA, WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H67 | Anti-Human NOTCH2 Recombinant Antibody (Tarextumab) | FuncS, Block, ELISA | IgG2 - kappa |
TAB-552MZ | Human Anti-NOTCH2 Recombinant Antibody (TAB-552MZ) | ELISA | Human IgG |
TAB-552MZ-S(P) | Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (TAB-552MZ-S(P)) | ELISA | Human scFv |
TAB-552MZ-F(E) | Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (TAB-552MZ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0038-CN-S(P) | Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (HPAB-0038-CN-S(P)) | FC, ELISA | Human scFv |
HPAB-0039-CN-S(P) | Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (HPAB-0039-CN-S(P)) | FC, ELISA | Human scFv |
HPAB-0595-WJ-S(P) | Human Anti-NOTCH2 Recombinant Antibody (clone D); scFv Fragment | ELISA, WB | Human scFv |
HPAB-0596-WJ-S(P) | Human Anti-NOTCH2 Recombinant Antibody (clone D-1); scFv Fragment | ELISA, WB | Human scFv |
HPAB-0597-WJ-S(P) | Human Anti-NOTCH2 Recombinant Antibody (clone D-2); scFv Fragment | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0038-CN-F(E) | Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (HPAB-0038-CN-F(E)) | FC, ELISA | Human Fab |
HPAB-0039-CN-F(E) | Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (HPAB-0039-CN-F(E)) | FC, ELISA | Human Fab |
HPAB-0595-WJ-F(E) | Human Anti-NOTCH2 Recombinant Antibody (clone D); Fab Fragment | ELISA, WB | Human Fab |
HPAB-0596-WJ-F(E) | Human Anti-NOTCH2 Recombinant Antibody (clone D-1); Fab Fragment | ELISA, WB | Human Fab |
HPAB-0597-WJ-F(E) | Human Anti-NOTCH2 Recombinant Antibody (clone D-2); Fab Fragment | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H67 | Afuco™ Anti-NOTCH2 ADCC Recombinant Antibody (Tarextumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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