Anti-RET Antibody Prodrug, Protease Activated (Y078)
CAT#: VS-1025-YC32
The Anti-RET Antibody Prodrug, Protease Activated (Y078) is an antibody prodrug comprised of a recombinant human antibody targeting human c-RET, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to RET protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to RET effectively. c-RET (Rearranged during Transfection) is a receptor tyrosine kinase whose activating mutations are critical in inherited cancers, such as Multiple Endocrine Neoplasia type 2 (MEN2), and whose fusions drive a subset of lung and thyroid cancers. These alterations cause constitutive kinase signaling. Highly specific RET inhibitors are effective in treating RET-fusion-positive tumors.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane, cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8356/1081_D1_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human parathyroid gland
Immunohistochemical staining of human parathyroid gland shows strong positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_3_8_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_B_8_5.jpg
Normal Tissue
Figure 4 Parathyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_3_8.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_4_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (MCF7, NB-4, SH-SY5Y, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165731-RET/subcellular
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human c-RET
- Target
- RET
- Species Reactivity
- Human
- Clone
- Y078
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
- Alternative Names
- PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1
- Gene ID
- 5979
- UniProt ID
- P07949
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone Y078"
- CAT
- Product Name
See other products for "RET"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-844 | Recombinant Anti-RET Antibody | ELISA, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-844-F(E) | Recombinant Anti-RET Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-844-S(P) | Recombinant Anti-RET Antibody scFv Fragment | FC, Neut, Funcs | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-844 | Recombinant Human Anti-RET Antibody | WB, Neut, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-844-F(E) | Recombinant Human Anti-RET Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-844-S(P) | Recombinant Human Anti-RET Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066MZ | Anti-Human RET Recombinant Antibody (Y078) | Cyt, IHC, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066MZ-S(P) | Anti-Human RET Recombinant Antibody scFv Fragment (Y078) | IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066MZ-F(E) | Anti-Human RET Recombinant Antibody Fab Fragment (Y078) | IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1794CT | Recombinant Mouse anti-Human RET Monoclonal antibody (NN0630-20G23) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-1148MZ | Chicken Anti-Human RET Polyclonal IgY | WB, ICC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3052 | Hi-Affi™ Recombinant Rabbit Anti-RET Monoclonal Antibody (DS3052AB) | WB, IHC, ICC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1331-CN | Recombinant Rabbit Anti-RET Monoclonal Antibody (CBACN-481) | WB, IF, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-065R | Mouse Anti-RET Recombinant Antibody (ZG-065R) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1001 | CytoStream™ Rabbit Anti-RET Recombinant Antibody (VS13-YC1001) | WB, ICC, IF, IHC-P, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC312 | Recombinant Anti-RET Vesicular Antibody, EV Displayed (VS-0425-YC312) | Cyt, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6083 | Anti-Mouse RET Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC292 | SmartAb™ Recombinant Anti-RET pH-dependent Antibody (Clone Y078) | Cyt, IHC, FC | Human IgG |
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