Anti-RET (clone Y078) Recombinant Antibody Coupled Liposome (VS-1024-FY40)
CAT#: VS-1024-FY40
Liposomes conjugated with anti-RET antibodies may have potential applications in the treatment of lung cancer. This strategy utilizes liposomes as drug delivery systems, enhancing therapeutic efficacy by targeting specific antibodies (such as anti-RET antibodies) to non-small cell lung cancer (NSCLC) cells. This type of nanotechnology shows significant promise in cancer treatment, but it also faces challenges such as drug efficacy and delivery efficiency.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane, cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8356/1081_D1_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human parathyroid gland
Immunohistochemical staining of human parathyroid gland shows strong positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_3_8_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_B_8_5.jpg
Normal Tissue
Figure 4 Parathyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_3_8.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_4_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (MCF7, NB-4, SH-SY5Y, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165731-RET/subcellular
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More Infomation
Specifications
- Potential Clinical Applications
- Lung cancer
Product Composition
- Clone
- Y078
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant antibody, which was specifically designed to target the RET protein. RET, or rearranged during transfection, is a crucial receptor tyrosine kinase that plays a significant role in various cellular processes, including cell growth, differentiation, and survival.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- RET
- Introduction
- This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
- Alternative Names
- Ret Proto-Oncogene; Cadherin-Related Family Member 16; Rearranged During Transfection; RET Receptor Tyrosine Kinase; Cadherin Family Member 12; Proto-Oncogene C-Ret; EC 2.7.10.1; CDHF12; CDHR16; PTC; Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease)
- Full Name
- Ret Proto-Oncogene
- Gene ID
- 5979
- UniProt ID
- P07949
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Endosome membrane; Single-pass type I membrane protein.
- Post Translation Modifications
- Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. ( P07949-RET_HUMAN )
Proteolytically cleaved by caspase-3.
The soluble RET kinase fragment is able to induce cell death.
- Protein Refseq
- NP_001342145.1; NP_001393672.1; NP_001393673.1; NP_001393688.1; NP_001393689.1
- Function
- Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15).
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-844-F(E) | Recombinant Anti-RET Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| MHH-844-F(E) | Recombinant Human Anti-RET Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-844-S(P) | Recombinant Anti-RET Antibody scFv Fragment | FC, Neut, Funcs | scFv |
| MHH-844-S(P) | Recombinant Human Anti-RET Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-844 | Recombinant Human Anti-RET Antibody | WB, Neut, FuncS | IgG |
| MOB-1794CT | Recombinant Mouse anti-Human RET Monoclonal antibody (NN0630-20G23) | WB | |
| MRO-1331-CN | Recombinant Rabbit Anti-RET Monoclonal Antibody (CBACN-481) | WB, IF, IHC, IP, FC | Rabbit IgG |
| ZG-065R | Mouse Anti-RET Recombinant Antibody (ZG-065R) | WB, ELISA | Mouse IgG |
| VS3-CJ479 | Rabbit Anti-RET Recombinant Antibody (VS3-CJ479) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066MZ | Anti-Human RET Recombinant Antibody (Y078) | Cyt, IHC, FC | Human antibody |
| TAB-066MZ-S(P) | Anti-Human RET Recombinant Antibody scFv Fragment (Y078) | IHC | Human antibody |
| TAB-066MZ-F(E) | Anti-Human RET Recombinant Antibody Fab Fragment (Y078) | IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-1148MZ | Chicken Anti-Human RET Polyclonal IgY | WB, ICC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3052 | Hi-Affi™ Recombinant Rabbit Anti-RET Monoclonal Antibody (DS3052AB) | WB, IHC, ICC, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1001 | CytoStream™ Rabbit Anti-RET Recombinant Antibody (VS13-YC1001) | WB, ICC, IF, IHC-P, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC312 | Recombinant Anti-RET Vesicular Antibody, EV Displayed (VS-0425-YC312) | Cyt, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6083 | Anti-Mouse RET Immunohistochemistry Kit | IHC |
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