Anti-RET (clone Y078) Recombinant Antibody Coupled Liposome (VS-1024-FY40) (CAT#: VS-1024-FY40)

• Potential Clinical Applications
• Lung cancer

• Clone
• Y078

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant antibody, which was specifically designed to target the RET protein. RET, or rearranged during transfection, is a crucial receptor tyrosine kinase that plays a significant role in various cellular processes, including cell growth, differentiation, and survival.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• RET

• Introduction
• This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.

• Alternative Names
• Ret Proto-Oncogene; Cadherin-Related Family Member 16; Rearranged During Transfection; RET Receptor Tyrosine Kinase; Cadherin Family Member 12; Proto-Oncogene C-Ret; EC 2.7.10.1; CDHF12; CDHR16; PTC; Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease)

• Full Name
• Ret Proto-Oncogene

• Gene ID
• 5979

• UniProt ID
• P07949

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Cell membrane; Single-pass type I membrane protein; Endosome membrane; Single-pass type I membrane protein.

• Post Translation Modifications
• Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. ( P07949-RET_HUMAN )
  Proteolytically cleaved by caspase-3.
  The soluble RET kinase fragment is able to induce cell death.

• Protein Refseq
• NP_001342145.1; NP_001393672.1; NP_001393673.1; NP_001393688.1; NP_001393689.1

• Function
• Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15).

• TAB-066MZ
• Anti-Human RET Recombinant Antibody (Y078)

• TAB-066MZ-S(P)
• Anti-Human RET Recombinant Antibody scFv Fragment (Y078)

• TAB-066MZ-F(E)
• Anti-Human RET Recombinant Antibody Fab Fragment (Y078)

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