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Anti-Human RET Recombinant Antibody Fab Fragment (Y078) (CAT#: TAB-066MZ-F(E))

The fully human anti-RET antibody may be conjugated to the DM1 and DM4 derivatives of the potent cytotoxic agent maytansine using thioether and disulfide linkers, respectively, which demonstrated antitumor activity in preclinical models.


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane, cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8356/1081_D1_2_selected.jpg
Figure 2 IHC staining of human parathyroid gland
Figure 2 IHC staining of human parathyroid gland
(Immunohistochemical staining of human parathyroid gland shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_3_8_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_B_8_5.jpg
Figure 4 Parathyroid gland
Figure 4 Parathyroid gland
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_3_8.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_4_6.jpg
Figure 6 Lymph node
Figure 6 Lymph node
(Germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2581/6496_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (MCF7, NB-4, SH-SY5Y, THP-1)
Figure 7 RNA cell line category: Cell line enhanced (MCF7, NB-4, SH-SY5Y, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165731-RET/subcellular

Specifications

  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • Y078
  • Applications
  • Immunohistochemistry
  • Related Disease
  • Breast cancer

Target

  • Alternative Names
  • PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone Y078"

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Recombinant Antibody

CAT Product Name Application Type
MOB-844 Recombinant Anti-RET Antibody ELISA, IP, FuncS IgG
MHH-844 Recombinant Human Anti-RET Antibody WB, Neut, FuncS IgG
MRO-1331-CN Recombinant Rabbit Anti-RET Monoclonal Antibody (CBACN-481) WB, IF, IHC, IP, FC Rabbit IgG
ZG-065R Mouse Anti-RET Recombinant Antibody (ZG-065R) WB, ELISA Mouse IgG
ZG-066R Mouse Anti-RET Recombinant Antibody (ZG-066R) WB, ELISA Mouse IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-844-F(E) Recombinant Anti-RET Antibody Fab Fragment RIA, WB, FuncS Fab
MHH-844-F(E) Recombinant Human Anti-RET Antibody Fab Fragment ELISA, WB, FC, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-844-S(P) Recombinant Anti-RET Antibody scFv Fragment FC, Neut, Funcs scFv
MHH-844-S(P) Recombinant Human Anti-RET Antibody scFv Fragment ELISA, WB, FuncS scFv

Human Antibody

CAT Product Name Application Type
TAB-066MZ Anti-Human RET Recombinant Antibody (Y078) Cyt, IHC, FC Human antibody
TAB-066MZ-S(P) Anti-Human RET Recombinant Antibody scFv Fragment (Y078) IHC Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-1148MZ Chicken Anti-Human RET Polyclonal IgY WB, ICC Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3052 Hi-Affi™ Recombinant Rabbit Anti-RET Monoclonal Antibody (DS3052AB) WB, IHC, ICC, IP, FC IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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