This product is a recombinant Mouse antibody that can recognize RSV F. 5C4 preferentially neutralizes subtype A viruses.
Figure 1 RSV neutralization
RSV neutralization by antibodies. Palivizumab is the FDA-approved prophylactic antibody that prevents severe RSV disease.
McLellan, J. S., Chen, M., Leung, S., Graepel, K. W., Du, X., Yang, Y., ... & Kumar, A. (2013). Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science, 340(6136), 1113-1117.
Figure 2 Antigenicity of RSV prefusion F and postfusion F.
Dots of pre-F, post-F, Heat Inactivated (HI-) pre-F, Formalin Inactivated (FI-) pre-F, RSV or FI-RSV are applied to a nitrocellulose membrane and blotted with antibody 5C4 similarly to a Western blot.
Killikelly, A. M., Kanekiyo, M., & Graham, B. S. (2016). Pre-fusion F is absent on the surface of formalin-inactivated respiratory syncytial virus. Scientific reports, 6, 34108.
Figure 3 Detection of monoclonal antibody binding to avian cells expressing chimeric F proteins. Representative monoclonal antibody binding to chimeric F protein-expressing cells was detected by flow cytometry.
Avian cells transfected with empty vector pCAGGS or pCAGGS containing the gene encoding the F/F, the DS-Cav1 F/F, the pre-F/F, or the post-F/F chimeric protein were incubated with MAb anti-F 5C4 antibody.
Cullen, L. M., Schmidt, M. R., Kenward, S. A., Woodland, R. T., & Morrison, T. G. (2015). Murine immune responses to virus-like particle-associated pre-and postfusion forms of the respiratory syncytial virus F protein. Journal of virology, 89(13), 6835-6847.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-009 | Anti-RSV Recombinant Antibody (Palivizumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
TAB-709 | Anti-RSV glycoprotein F Recombinant Antibody (Motavizumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
MRO-1209LC | Anti-HRSV F Recombinant Antibody (MEDI-493) | ELISA, Neut, PK | Humanized antibody |
MRO-1209LC-S(P) | Anti-HRSV F Recombinant Antibody scFv Fragment (MEDI-493) | ELISA | Humanized antibody |
MRO-1209LC-F(E) | Anti-HRSV F Recombinant Antibody Fab Fragment (MEDI-493) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-358CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-358CT-S(P)) | ELISA, WB, Neut, IF, FC | Human scFv |
TAB-361CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-361CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
TAB-362CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-362CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
TAB-363CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-363CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
TAB-364CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-364CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-878LC-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (MRO-878LC-S(P)) | ELISA, Neut | Human scFv |
HPAB-0293CQ-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (HPAB-0293CQ-S(P)) | ELISA, Neut | Human scFv |
PSBC-494 | Recombinant Human Anti-RSV F Antibody scFv Fragment (14N4) | ELISA, Neut | Human scFv |
PABJ-0100-S(P) | Mouse Anti-RSV F Recombinant Antibody (clone R4.C6); scFv Fragment | ELISA, Neut | Mouse scFv |
PABJ-0166-S(P) | Human Anti-RSV F Recombinant Antibody (clone RSD5); scFv Fragment | ELISA, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-878LC-F(E) | Human Anti-RSV F Recombinant Antibody; Fab Fragment (MRO-878LC-F(E)) | ELISA, Neut | Human Fab |
HPAB-0293CQ-F(E) | Human Anti-RSV F Recombinant Antibody; Fab Fragment (HPAB-0293CQ-F(E)) | ELISA, Neut | Human Fab |
PFBC-276 | Recombinant Mouse Anti-RSV F Antibody Fab Fragment (5C4) | ELISA, Neut | Mouse Fab |
HPAB-0105-WJ-F(E) | Human Anti-RSV F Recombinant Antibody; Fab Fragment (HPAB-0105-WJ-F(E)) | ELISA, WB | Human Fab |
PABJ-0166-F(E) | Human Anti-RSV F Recombinant Antibody (clone RSD5); Fab Fragment | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1210LC | Anti-HRSV F Recombinant Antibody (C11) | ELISA | Mouse Antibody |
MRO-1211LC | Anti-HRSV F Recombinant Antibody (C13) | ELISA | Mouse Antibody |
MRO-1210LC-S(P) | Anti-HRSV F Recombinant Antibody scFv Fragment (C11) | ELISA | Mouse Antibody |
MRO-1210LC-F(E) | Anti-HRSV F Recombinant Antibody Fab Fragment (C11) | ELISA | Mouse Antibody |
MRO-1211LC-F(E) | Anti-HRSV F Recombinant Antibody Fab Fragment (C13) | ELISA | Mouse Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0293CQ | Human Anti-RSV F Recombinant Antibody (HPAB-0293CQ) | ELISA, Neut, FuncS | Human IgG1 |
PABC-494 | Recombinant Human Anti-RSV F Antibody (14N4) | SPR, ELISA, Neut | Human IgG1, κ |
PABS-0157 | Human Anti-RSV F Recombinant Antibody (clone C57) | FC, ELISA | Human IgG |
PABS-0166 | Human Anti-RSV F Recombinant Antibody (clone MEDI8897) | ELISA, Neut, FuncS | Human IgG |
PABJ-0166 | Human Anti-RSV F Recombinant Antibody (clone RSD5) | ELISA, Neut | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-009 | Afuco™ Anti-RSV F ADCC Recombinant Antibody (Palivizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-709 | Afuco™ Anti-RSV F ADCC Recombinant Antibody (Motavizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YC250 | H-2Kd/Respiratory syncytial virus Fusion protein (F) (KYKNAVTEL) MHC Pentamer | FCM |
There are currently no Customer reviews or questions for PABC-276. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.