Human Anti-RSV F Recombinant Antibody (TAB-358CT) (CAT#: TAB-358CT)

This product is a recombinant Human antibody that recognizes RSV F. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.

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Specifications

  • Immunogen
  • RSV F protein
  • Host Species
  • Human
  • Type
  • Human IgG1, κ
  • Specificity
  • RSV F
  • Species Reactivity
  • Respiratory syncytial virus
  • Applications
  • ELISA, WB, Neut, IF, FC
  • Related Disease
  • RSV infection

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • RSV-F; Respiratory Syncytial Virus F protein; RSV F; anti-RSV-F

Related Resources

  • Citations

Cui, Guanglin, et al. "Preliminary functional and phylogeographic analyses of the 72 nucleotide duplication region in the emerging human respiratory syncytial virus ON1 strain attachment glycoprotein gene." Biomedicine & Pharmacotherapy 123 (2020): 109800.

This study investigates the emerging human respiratory syncytial virus (hRSV) ON1 strain, which is characterized by a 72-nucleotide duplication in the attachment glycoprotein (G) gene. The research utilized a pseudotype lentiviral system to examine the impact of this duplication on hRSV infection. The findings revealed that lentiviral pseudoparticles mimicked the essential functions of the G-protein in facilitating hRSV cell entry and that the deletion of the G-protein duplication significantly reduced the efficiency of pseudotyped lentiviral (pLV) infection. Additionally, the study performed Bayesian skyline and phylogeographic analyses on 199 ON1 sequences, providing insights into the evolutionary and geographical origins of the ON1 strain.
Creative Biolabs provided crucial monoclonal antibodies for this study. The anti-G monoclonal antibody 131-2G (CAT#: TAB-372CT) and the anti-F monoclonal antibody (CAT#: TAB-358CT) were used in Western immunoblotting to confirm the incorporation of G and F proteins into the pseudoparticles. Furthermore, the anti-G monoclonal antibody 131-2G (CAT#: TAB-372CT) was employed in antibody blockade experiments to demonstrate the role of the G protein in hRSV cell entry. These antibodies were essential for verifying the functionality of the pseudotyped lentiviral particles and for the subsequent functional analyses.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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CAT Product Name Application Type
TAB-009 Anti-RSV Recombinant Antibody (Palivizumab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-709 Anti-RSV glycoprotein F Recombinant Antibody (Motavizumab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
MRO-1209LC Anti-HRSV F Recombinant Antibody (MEDI-493) ELISA, Neut, PK Humanized antibody
MRO-1209LC-S(P) Anti-HRSV F Recombinant Antibody scFv Fragment (MEDI-493) ELISA Humanized antibody
MRO-1209LC-F(E) Anti-HRSV F Recombinant Antibody Fab Fragment (MEDI-493) ELISA Humanized antibody

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To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-358CT, RRID: AB_3111918)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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