Anti-HRSV F Recombinant Antibody (MEDI-493) (CAT#: MRO-1209LC)
This product is a recombinant humanized anti-Respiratory syncytial virus monoclonal antibody. MEDI-493 specifically binds to F glycoprotein associated with RSV and can be potentially used in the diagnosis and treatment of Respiratory syncytial virus infection.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Neut
Figure 1 Plaque-reduction assay of neutralization of RSV by MEDI-493.
O ^ RSV Long (A subtype) -f- MEDI-493; A = RSV 18537 (B subtype) H- MEDI-493; = RSV Long -I- RSV intravenous immune globulin (lot 4).
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus
Neut
Figure 2 Microneutralization assay of MEDI-493 and RSV in- travenous immune globulin (IVIG) using clinical isolates of RSV.
O = MEDI-493; = RSV IVIG; A ^ no antibody added.
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus
PK
Figure 3 Single-dose serum pharmacokinetics and lung bio-distribution of palivizumab, AFFF and A4b4 in cotton rats.
Antibodies at 3 mg/kg were administered by i.m. injection. Animals were bled retro-orbitally at various times after antibody infusion, and serum human IgG titers were measured by ELISA.
Development of Motavizumab, an Ultra-potent Antibody for the Prevention of Respiratory Syncytial Virus Infection in the Upper and Lower Respiratory Tract
PK
Figure 4 Pharmacokinetics of palivizumab, A4b4, A4b4-F52S (shown as F52S) and 493L1FR-S29R (motavizumab) in cynomolgus monkeys.
A single dose at 30 mg/kg of palivizumab or its variants was administered to cynomolgus monkeys by i.v. injection.
Development of Motavizumab, an Ultra-potent Antibody for the Prevention of Respiratory Syncytial Virus Infection in the Upper and Lower Respiratory Tract
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human Respiratory syncytial virus
- Clone
- MEDI-493
- Applications
- ELISA, Neut, PK
- Related Disease
- Respiratory syncytial virus infection
Applications
- Application Notes
- The RSV F antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization, Pharmacokinetic.
Target
- Alternative Names
- Respiratory syncytial virus; RSV; Respiratory syncytial virus fusion glycoprotein; RSV F
- Gene ID
- 1489825
- UniProt ID
- O36634
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody Products
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MHC Tetramer Products for Virology
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009 | Human Anti-RSV Recombinant Antibody (TAB-009) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-709 | Anti-RSV glycoprotein F Recombinant Antibody (TAB-709) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| MRO-1209LC-S(P) | Anti-HRSV F Recombinant Antibody scFv Fragment (MEDI-493) | ELISA | Humanized antibody |
| MRO-1209LC-F(E) | Anti-HRSV F Recombinant Antibody Fab Fragment (MEDI-493) | ELISA | Humanized antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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