Anti-SDC1 Antibody-Cytokine Fusion Protein, IgG (B-B4)-IFNα14
CAT#: VS-0624-FY80
B-B4 is a human monoclonal antibody that was meticulously crafted to specifically target the extracellular portion of CD138. Natural human IFN-α14 was induced in peripheral blood mononuclear cells after incubation with CpG oligonucleotides and in plasmacytoid dendritic cells after incubation with CpG oligonucleotides or imiquimod. This product comprises an anti-human CD138-INFα14 fusion protein that integrates the V region of the anti-CD138 mouse antibody B-B4 with the human IgG1, κappa constant region. The linkage between the anti-CD138 and INFα14 is established through a SGGGGS linker.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_3.jpg
Normal Tissue
Figure 4 Testis
Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_4_6.jpg
Normal Tissue
Figure 5 Placenta
Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115884-SDC1
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Specifications
- Target
- CD138
- Molecule Class
- IgG-IFNα14
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- B-B4
- Related Disease
- Monoclonal Gammopathy Of Uncertain Significance and Endometritis
- Cytokine 1
- IFNα14
- Cytokines 1 Description
- Predicted to activate cytokine activity and type I interferon receptor binding activity. Predicted to be involved in multiple processes including B-cell activation; activation of lymphocytes involved in immune responses; and positive regulation of peptidyl serine phosphorylation of STAT proteins.
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
- Alternative Names
- Syndecan 1; Syndecan Proteoglycan 1; CD138 Antigen; SYND1; SDC; Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor; Syndecan-1; Syndecan; CD138; Anti-CD138-IFNα14
- Gene ID
- 6382
- UniProt ID
- P18827
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Datasheet
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COA
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