What applications can this antibody be used for?

This mouse anti-TFRC recombinant antibody, specifically the scFv Fragment, can be used primarily in ELISA. Its specificity for the transferrin receptor makes it useful in studies focusing on iron metabolism and the cellular uptake of iron.

What is the significance of targeting TFRC?

TFRC, or transferrin receptor, is key in cellular iron uptake through transferrin binding and endocytosis. Understanding TFRC interactions can help in studies related to cancer, as many tumor cells show high transferrin receptor expression, making it a focus in cancer research.

Does the antibody come with any conjugation options?

While the base product comes unconjugated, Creative Biolabs offers options for various conjugations like PE, APC, Biotin, FITC, and HRP, allowing flexibility for different assay needs.

Mouse Anti-TFRC Recombinant Antibody (clone OX26); scFv Fragment

CAT#: FAMAB-0281-YC-S(P)

The OX26 murine monoclonal antibody scFv Fragment to the rat tansferrin receptor binds an exofacial epitope on this receptor.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg

Normal Tissue Figure 5 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg

Normal Tissue Figure 6 Testis

Leydig cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Pachytene spermatocytes
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg

Normal Tissue Figure 7 Bone marrow

Hematopoietic cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg

Normal Tissue Figure 8 Lymph node

Germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC

❮

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Specifications

Host Species
Mouse

Type
Mouse scFv

Specificity
Rat TFRC

Species Reactivity
Rat

Clone
OX26

Applications
ELISA

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Trfr

Gene ID
64678

UniProt ID
G3V679

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Breast cancer biomarkers at key points during disease progression

Great for Iron Metabolism Studies

We have been using this antibody in our ongoing research on iron metabolism. Its specificity towards the transferrin receptor offered us clear insights into iron uptake processes, helping us develop more refined models for our studies.

Dependable Research Tool

The scFv fragment of the Mouse Anti-TFRC Antibody has been a reliable addition to our lab's toolbox. It showed precise results in our ELISA tests targeting the transferrin receptor. Easy to store and handle, definitely a great asset for our biochemical studies.

Q&As

What applications can this antibody be used for?

A: This mouse anti-TFRC recombinant antibody, specifically the scFv Fragment, can be used primarily in ELISA. Its specificity for the transferrin receptor makes it useful in studies focusing on iron metabolism and the cellular uptake of iron.
What is the significance of targeting TFRC?

A: TFRC, or transferrin receptor, is key in cellular iron uptake through transferrin binding and endocytosis. Understanding TFRC interactions can help in studies related to cancer, as many tumor cells show high transferrin receptor expression, making it a focus in cancer research.
Does the antibody come with any conjugation options?

A: While the base product comes unconjugated, Creative Biolabs offers options for various conjugations like PE, APC, Biotin, FITC, and HRP, allowing flexibility for different assay needs.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - FAMAB-0281-YC-S(P).pdf

MSDS

MSDS - FAMAB-0281-YC-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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