Human Anti-TPO Recombinant Antibody (clone ICA5) (CAT#: FAMAB-0042JF)
Recombinant monoclonal antibody specially binds to TPO. This human monoclonal anti-TPO antibody (ICA5) is useful in studing the pathogenesis of thyroid autoimmune diseases.
Specific Inquiry
Neut
Figure 1 Human Anti-TPO Antibody (clone ICA5) in Neut.
Binding inhibition of anti-TPO ICA1, ICA5, and ICB7 scFvs to adsorbed TPO by increasing concentrations of soluble TPO (•), Tg (□), lactoperoxidase (▪), and HRP (▴).
Chapal, N., Peraldi-Roux, S., Bresson, D., Pugniere, M., Mani, J. C., Granier, C., ... & Bouanani, M. (2000). Human anti-thyroid peroxidase single-chain fragment variable of Ig isolated from a combinatorial library assembled in-cell: insights into the in vivo situation. The Journal of Immunology, 164(8), 4162-4169.
SPR
Figure 2 Human Anti-TPO Antibody (clone ICA5) in SPR.
Surface plasmon resonance analysis of the binding of scFvs ICA1, ICB7, and ICA5 and control scFv IC10 to immobilized TPO. Sensorgrams for the kinetic analysis of the interaction of these scFvs with TPO.
Chapal, N., Peraldi-Roux, S., Bresson, D., Pugniere, M., Mani, J. C., Granier, C., ... & Bouanani, M. (2000). Human anti-thyroid peroxidase single-chain fragment variable of Ig isolated from a combinatorial library assembled in-cell: insights into the in vivo situation. The Journal of Immunology, 164(8), 4162-4169.
Neut
Figure 3 Human Anti-TPO Antibody (clone ICA5) in Neut.
Binding inhibition of anti-TPO ICA1, ICA5, and ICB7 scFvs by the sera from the 29 Graves' disease patients. No inhibition was observed with normal sera.
Chapal, N., Peraldi-Roux, S., Bresson, D., Pugniere, M., Mani, J. C., Granier, C., ... & Bouanani, M. (2000). Human anti-thyroid peroxidase single-chain fragment variable of Ig isolated from a combinatorial library assembled in-cell: insights into the in vivo situation. The Journal of Immunology, 164(8), 4162-4169.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- Human TPO
- Species Reactivity
- Human
- Clone
- ICA5
- Applications
- WB, ELISA, FuncS
- Related Disease
- Graves' disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Related Resources
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone ICA5"
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-999-F(E) | Recombinant Anti-TPO Antibody Fab Fragment | ELISA, Nert, FuncS | Fab |
| MHH-999-F(E) | Recombinant Human Anti-TPO Antibody Fab Fragment | IP, IF, FuncS | Fab |
| PFBW-123 | Human Anti-TPO Recombinant Antibody (clone TR1.9); Fab Fragment | WB, ELISA | Human Fab |
| HPAB-2017-FY-F(E) | Human Anti-TPO Recombinant Antibody (clone FY-019); Fab Fragment | ELISA | Human Fab |
| FAMAB-0364JF-F(E) | Human Anti-TPO Recombinant Antibody (clone RI-34); Fab Fragment | ELISA, FuncS | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-999 | Recombinant Human Anti-TPO Antibody | WB, ELISA, IHC, FuncS | IgG |
| MOB-1174MZ | Recombinant Mouse Anti-Human TPO Antibody (clone NpBc58) | IHC-P | Mouse antibody |
| HPAB-2017-FY | Human Anti-TPO Recombinant Antibody (clone FY-019) | ELISA | Human IgG |
| FAMAB-0364JF | Human Anti-TPO Recombinant Antibody (clone RI-34) | ELISA, FuncS | Human IgG |
| VS3-FY1477 | Recombinant Mouse Anti-TPO Antibody (clone 9G3-6F3-9B7) | IHC-P | Mouse IgG2b |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2215CQ | Mouse Anti-TPO Recombinant Antibody (clone CBL296) | Neut, ELISA | Mouse IgG2b |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3658 | Rabbit Anti-TPO Recombinant Antibody (clone DS3658AB) | IHC-P, IP, WB | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4548 | PE-DQB1*03:02/Human TPO (IDVWLGGLAENFLP) MHC Tetramer | FCM |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0013JF-S(P) | Human Anti-TPO Recombinant Antibody (clone A12); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0014JF-S(P) | Human Anti-TPO Recombinant Antibody (clone B8); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0015JF-S(P) | Human Anti-TPO Recombinant Antibody (clone T5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0036JF-S(P) | Human Anti-TPO Recombinant Antibody (clone TF3.5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| FAMAB-0042JF-S(P) | Human Anti-TPO Recombinant Antibody (clone ICA5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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