Human Anti-VCAM1 Recombinant Antibody (clone 7H); scFv Fragment

Name: Human Anti-VCAM1 Recombinant Antibody (clone 7H); scFv Fragment
SKU: HPAB-0860-CN-S(P)
Rating: 5 (1 reviews)

CAT#: HPAB-0860-CN-S(P)

This is a human monoclonal antibody that specifically binds to VCAM-1. 7H shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby can be used for the treatment of cancer or inflammatory disease.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69867/1706_F12_18_cr57d839e75f94b_selected.jpg

Normal Tissue Figure 2 Kidney

Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Distal tubules Staining: Medium Intensity: Strong Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/154/2835_A_8_5.jpg

Normal Tissue Figure 3 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/154/2835_A_6_6.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/154/2835_A_8_8.jpg

Normal Tissue Figure 5 High expression in spleen

Cells in red pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/154/2835_B_7_4.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (HHSteC, HSkMC)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162692-VCAM1

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Specifications

Immunogen
hVACM1-D1-D-His antigen

Host Species
Human

Derivation
scFv phage display library

Type
Human scFv

Specificity
Human VCAM1

Species Reactivity
Human, Mouse

Clone
7H

Applications
ELISA, Neut

Related Disease
Inflammatory diseases, Cancer

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Vascular Cell Adhesion Molecule 1; CD106 Antigen; INCAM-100; Vascular Cell Adhesion Protein 1; V-CAM 1; VCAM-1; CD106;

Gene ID
7412

UniProt ID
P19320

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Related Signaling Pathways

TNF Signaling Pathway

Related Diseases

AGE-RAGE Signaling Pathway in Diabetic Complications

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0860-CN-S(P).pdf

MSDS

MSDS - HPAB-0860-CN-S(P).pdf

COA

Certificate of Analysis Lookup

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