Human Anti-VEGFA Recombinant Antibody (clone VG76e) (CAT#: FAMAB-1289CQ)

Figure 1 Effect of VEGF antibody, VG76e, on VEGF-mediated HUVEC growth.

Results are given as a percentage of the control value, where cells were grown in the presence of VEGF alone. Results show the mean ± SD of three independent experiments for VG76e and two experiments for positive control VEGF antibody, 2C3, and control IgG. Both VEGF antibodies exhibited a marked inhibitory effect on VEGF-stimulated proliferation of HUVECs. A negative control anti-body of irrelevant specificity had no effect on endothelial cell growth.

Fraser, H. M., Dickson, S. E., Lunn, S. F., Wulff, C., Morris, K. D., Carroll, V. A., & Bicknell, R. (2000). Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology, 141(3), 995-1000.

Figure 2 Photomicrographs of toluidine blue-stained corpora lutea to show the appearance of hormone-producing lutein cells in the midlutealcorpus luteum of anti-VEGF-treated marmosets.

Note how the lutein cells of the treated animal are more closely packed, and the cluster of densely stained cells (arrows) presumably of luteal origin. Scale bars, 50 μm.

Fraser, H. M., Dickson, S. E., Lunn, S. F., Wulff, C., Morris, K. D., Carroll, V. A., & Bicknell, R. (2000). Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor. Endocrinology, 141(3), 995-1000.