Anti-Trop-2 (clone 7E6)-AcLys-vc-PABC-MMAD ADC (CAT#: ADC-343CL)

• Antibody Overview
• Chimeric Anti-Trop-2 Antibody 7E6 K222R variant (transglutaminase tag LCQ03)

• Clone
• 7E6

• Linker
• AcLys-VC-
  PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl)

• Drug
• MMAD (monomethyl auristatin D)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

• Alternative Names
• TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;

• Gene ID
• 4070

• UniProt ID
• P09758

• ADC-344CL
• Anti-Trop-2 (clone 7E6)-AcLys-vc-PABC-MMAD ADC

• ADC-345CL
• Anti-Trop-2 (clone 7E6)-AcLys-vc-PABC-MMAD ADC

• ADC-346CL
• Anti-Trop-2 (clone 7E6)-PEG6-MMAD ADC

• ADC-347CL
• Anti-Trop-2 (clone 7E6)-AcLys-VC-PABC-MMAD

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