Anti-Trop-2 (clone 7E6)-AcLys-VC-PABC-MMAD (CAT#: ADC-347CL)

• Antibody Overview
• Humanized Anti-Trop-2 Antibody (h7E6SVG)

• Clone
• 7E6

• Linker
• AcLys-VC-
  PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl)

• Drug
• 2-methylalanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidin-1-yl}-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide)

• Introduction
• This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

• Alternative Names
• TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;

• Gene ID
• 4070

• UniProt ID
• P09758

• ADC-343CL
• Anti-Trop-2 (clone 7E6)-AcLys-vc-PABC-MMAD ADC

• ADC-344CL
• Anti-Trop-2 (clone 7E6)-AcLys-vc-PABC-MMAD ADC

• ADC-345CL
• Anti-Trop-2 (clone 7E6)-AcLys-vc-PABC-MMAD ADC

• ADC-346CL
• Anti-Trop-2 (clone 7E6)-PEG6-MMAD ADC

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