Human Anti-GPC3 (clone codrituzumab) scFv-Fc Chimera (CAT#: VS-0325-FY182)
The anti-GPC3 scFv-Fc antibody is developed to target Glypican-3 (GPC3), a heparan sulfate proteoglycan often overexpressed in certain cancers. This antibody leverages the scFv-Fc format to provide specific targeting and enhanced stability, making it a valuable tool for research into GPC3's role in oncogenesis and its potential as a biomarker or therapeutic target.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6316/1404_H7_2_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6316/1404_H7_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HAP1, Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147257-GPC3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147257-GPC3
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPC3
- Species Reactivity
- Human
- Clone
- codrituzumab
- Applications
- Immunofluorescence, Neutralization, ELISA, Flow Cytometry, Immunoprecipitation, ICC
- Related Disease
- Hepatocellular carcinoma (HCC)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glypican 3; Intestinal Protein OCI-5; Glypican Proteoglycan 3; GTR2-2; MXR7; Heparan Sulphate Proteoglycan; Secreted Glypican-3; Glypican-3
- Gene ID
- 2719
- UniProt ID
- P51654
- Long Name
- Glypican 3
- Sequence Similarities
- Belongs to the glypican family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- O-glycosylated; contains heparan sulfate and/or chondroitin sulfate.
Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor.
This processing is essential for its role in inhibition of hedgehog signaling.
A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface.
Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_016884902.1; XP_054182809.1; NP_001158089.1; NP_001158090.1; NP_001158091.1
- Function
- Human GPC3 (Glypican 3) is a cell surface protein involved in cell growth and differentiation, often overexpressed in hepatocellular carcinoma. It serves as a target for cancer therapy.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-069 | Recombinant Anti-Mouse Gpc3 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| TAB-416CQ | Anti-Human GPC3 Single Domain Antibody (TAB-416CQ), Research Grade Biosimilar | IP, IHC, FuncS, WB, ELISA, Inhib | Single domain antibody |
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