Human Anti-GPC3 (clone codrituzumab) scFv-Fc Chimera (CAT#: VS-0325-FY182)
The anti-GPC3 scFv-Fc antibody is developed to target Glypican-3 (GPC3), a heparan sulfate proteoglycan often overexpressed in certain cancers. This antibody leverages the scFv-Fc format to provide specific targeting and enhanced stability, making it a valuable tool for research into GPC3's role in oncogenesis and its potential as a biomarker or therapeutic target.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6316/1404_H7_2_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6316/1404_H7_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HAP1, Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147257-GPC3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147257-GPC3
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPC3
- Species Reactivity
- Human
- Clone
- codrituzumab
- Applications
- Immunofluorescence, Neutralization, ELISA, Flow Cytometry, Immunoprecipitation, ICC
- Related Disease
- Hepatocellular carcinoma (HCC)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glypican 3; Intestinal Protein OCI-5; Glypican Proteoglycan 3; GTR2-2; MXR7; Heparan Sulphate Proteoglycan; Secreted Glypican-3; Glypican-3
- Gene ID
- 2719
- UniProt ID
- P51654
- Long Name
- Glypican 3
- Sequence Similarities
- Belongs to the glypican family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- O-glycosylated; contains heparan sulfate and/or chondroitin sulfate.
Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor.
This processing is essential for its role in inhibition of hedgehog signaling.
A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface.
Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_016884902.1; XP_054182809.1; NP_001158089.1; NP_001158090.1; NP_001158091.1
- Function
- Human GPC3 (Glypican 3) is a cell surface protein involved in cell growth and differentiation, often overexpressed in hepatocellular carcinoma. It serves as a target for cancer therapy.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "GPC3"
Select a product category from the dropdown menu below to view related products.
Please select product type
Single Domain Antibody Products
Humanized Antibody Products
Immunotoxin Products
IgG Antibody Products
Chimeric Antibody Products
Human Antibody Products
Mouse Antibody Products
MHC Tetramer Products for Cancer
Rabbit Monoclonal Antibody Products
ADCC Enhanced Antibody Products
Fab Antibody Products
ScFv Antibody Products
Antibody Magnetic Beads
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-069 | Recombinant Anti-Mouse Gpc3 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| TAB-416CQ | Anti-Human GPC3 Single Domain Antibody (TAB-416CQ), Research Grade Biosimilar | IP, IHC, FuncS, WB, ELISA, Inhib | Single domain antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY182. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, IF, IHC, WB
Application: ELISA, FC, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
