Human Anti-GPC3 (clone codrituzumab) scFv-Fc Chimera

Name: Human Anti-GPC3 (clone codrituzumab) scFv-Fc Chimera
SKU: VS-0325-FY182
Rating: 5 (1 reviews)

CAT#: VS-0325-FY182

The anti-GPC3 scFv-Fc antibody is developed to target Glypican-3 (GPC3), a heparan sulfate proteoglycan often overexpressed in certain cancers. This antibody leverages the scFv-Fc format to provide specific targeting and enhanced stability, making it a valuable tool for research into GPC3's role in oncogenesis and its potential as a biomarker or therapeutic target.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line Hep G2

Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6316/1404_H7_2_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (HAP1, Hep G2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147257-GPC3

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Specifications

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
Human GPC3

Species Reactivity
Human

Clone
codrituzumab

Applications
Immunofluorescence, Neutralization, ELISA, Flow Cytometry, Immunoprecipitation, ICC

Related Disease
Hepatocellular carcinoma (HCC)

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Target

Alternative Names
Glypican 3; Intestinal Protein OCI-5; Glypican Proteoglycan 3; GTR2-2; MXR7; Heparan Sulphate Proteoglycan; Secreted Glypican-3; Glypican-3

Gene ID
2719

UniProt ID
P51654

Long Name
Glypican 3

Sequence Similarities
Belongs to the glypican family.

Cellular Localization
Cell membrane

Post Translation Modifications
O-glycosylated; contains heparan sulfate and/or chondroitin sulfate.
Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor.
This processing is essential for its role in inhibition of hedgehog signaling.
A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface.
Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)

Protein Refseq
XP_016884902.1; XP_054182809.1; NP_001158089.1; NP_001158090.1; NP_001158091.1

Function
Human GPC3 (Glypican 3) is a cell surface protein involved in cell growth and differentiation, often overexpressed in hepatocellular carcinoma. It serves as a target for cancer therapy.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0325-FY182.pdf

MSDS

MSDS - VS-0325-FY182.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

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Secondary Antibody

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