Human Anti-GPC3 (clone codrituzumab) scFv-Fc Chimera (CAT#: VS-0325-FY182)
The anti-GPC3 scFv-Fc antibody is developed to target Glypican-3 (GPC3), a heparan sulfate proteoglycan often overexpressed in certain cancers. This antibody leverages the scFv-Fc format to provide specific targeting and enhanced stability, making it a valuable tool for research into GPC3's role in oncogenesis and its potential as a biomarker or therapeutic target.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

(Immunofluorescent staining of human cell line Hep G2 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6316/1404_H7_2_selected.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147257-GPC3
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPC3
- Species Reactivity
- Human
- Clone
- codrituzumab
- Applications
- Immunofluorescence, Neutralization, ELISA, Flow Cytometry, Immunoprecipitation, ICC
- Related Disease
- Hepatocellular carcinoma (HCC)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glypican 3; Intestinal Protein OCI-5; Glypican Proteoglycan 3; GTR2-2; MXR7; Heparan Sulphate Proteoglycan; Secreted Glypican-3; Glypican-3
- Gene ID
- 2719
- UniProt ID
- P51654
- Long Name
- Glypican 3
- Sequence Similarities
- Belongs to the glypican family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- O-glycosylated; contains heparan sulfate and/or chondroitin sulfate.
Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor.
This processing is essential for its role in inhibition of hedgehog signaling.
A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface.
Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 7 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_016884902.1; XP_054182809.1; NP_001158089.1; NP_001158090.1; NP_001158091.1
- Function
- Human GPC3 (Glypican 3) is a cell surface protein involved in cell growth and differentiation, often overexpressed in hepatocellular carcinoma. It serves as a target for cancer therapy.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "GPC3"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1563z | Mouse Anti-GPC3 Recombinant Antibody (clone 29F5) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
HPAB-M0275-YC | Human Anti-GPC3 Recombinant Antibody (clone M/YC-28) | ELISA | Human IgG1 |
HPAB-0449-FY | Mouse Anti-GPC3 Recombinant Antibody (HPAB-0449-FY) | ELISA | Mouse IgG2 |
VS4-WK199 | Human Anti-GPC3 Recombinant Antibody (clone 4C3) | ELISA | Human IgG |
VS4-WK200 | Mouse Anti-GPC3 Recombinant Antibody (clone 6F1B5) | ELISA, WB, FC | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
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