Human Anti-GPC3 (clone codrituzumab) scFv-Fc Chimera (CAT#: VS-0325-FY182)

The anti-GPC3 scFv-Fc antibody is developed to target Glypican-3 (GPC3), a heparan sulfate proteoglycan often overexpressed in certain cancers. This antibody leverages the scFv-Fc format to provide specific targeting and enhanced stability, making it a valuable tool for research into GPC3's role in oncogenesis and its potential as a biomarker or therapeutic target.

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Formats:
  • Isotype Switching:
  • Fc Engineering:
  • Modalities:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Specificity
  • Human GPC3
  • Species Reactivity
  • Human
  • Clone
  • codrituzumab
  • Applications
  • Immunofluorescence, Neutralization, ELISA, Flow Cytometry, Immunoprecipitation, ICC
  • Related Disease
  • Hepatocellular carcinoma (HCC)

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Target

  • Alternative Names
  • Glypican 3; Intestinal Protein OCI-5; Glypican Proteoglycan 3; GTR2-2; MXR7; Heparan Sulphate Proteoglycan; Secreted Glypican-3; Glypican-3
  • Long Name
  • Glypican 3
  • Sequence Similarities
  • Belongs to the glypican family.
  • Cellular Localization
  • Cell membrane
  • Post Translation Modifications
  • O-glycosylated; contains heparan sulfate and/or chondroitin sulfate.
    Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor.
    This processing is essential for its role in inhibition of hedgehog signaling.
    A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface.
    Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyGen 7 sites, 9 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
  • Function
  • Human GPC3 (Glypican 3) is a cell surface protein involved in cell growth and differentiation, often overexpressed in hepatocellular carcinoma. It serves as a target for cancer therapy.

Recommended Products

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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