Human Anti-IL1RL1 (clone chKM1732) scFv-Fc Chimera
CAT#: VS-0425-FY2
Anti-IL1RL1 scFv-Fc neutralizes IL1RL1 signaling by binding to the receptor, preventing its interaction with its ligands (such as IL-33). This interaction inhibits the downstream signaling pathways that lead to inflammatory responses, making this product a promising candidate for the treatment of conditions characterized by excessive IL1RL1 activation, including asthma, rheumatoid arthritis, and other inflammatory diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane, cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/44_B9_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows membranous and cytoplasmic positivity in trophoblastic cells and stromal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7917/ihc_selected.jpg
Normal Tissue
Figure 5 Colon
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/23807_A_7_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/23807_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/23807_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/23807_A_6_6.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7406/23807_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Group enriched (HHSteC, HMC-1, HUVEC TERT2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115602-IL1RL1
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Specifications
- Immunogen
- Human VEGF receptor Flt-1 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The chKM1732 antibody specifically reacts with human VEGF receptor Flt-1.
- Species Reactivity
- Human
- Clone
- chKM1732
- Applications
- Western Blot, Immunohistochemistry, Immunoprecipitation, ELISA, Neutralization
- Related Disease
- Chicken Egg Allergy and Asthma
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 1 Receptor Like 1
- Gene ID
- 9173
- UniProt ID
- Q01638
- Long Name
- Interleukin 1 Receptor Like 1
- Sequence Similarities
- Belongs to the interleukin-1 receptor family.
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Ubiquitinated at Lys-321 in a FBXL19-mediated manner; leading to proteasomal degradation.
Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response.
Glycosylation at Asn140, Asn54, Asn191, Asn95, Asn101, Asn232, Asn254, and Asn273
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ILRL1_HUMAN (1948)
Glycosylation from GlyGen 8 sites, 11 N-linked glycans (5 sites)
- Protein Refseq
- XP_006712902.1; XP_011510453.1; XP_054200480.1; XP_054200481.1; NP_001269337.1
- Function
- Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP.
Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8.
Possibly involved in helper T-cell function (Probable).
Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-560 | Recombinant Anti-human IL1RL1 Antibody | ELISA, WB, IP, FuncS | IgG |
| PABL-704 | Human Anti-IL1RL1 Recombinant Antibody (clone C2244) | WB, IF, FuncS | Human IgG |
| TAB-222CT | Mouse Anti-IL1RL1 Recombinant Antibody (TAB-222CT) | ELISA, Inhib, FC | Mouse IgG1 |
| MOB-370YC | Recombinant Mouse Anti-IL1RL1 Capture Antibody (MOB-350YC) | ELISA | Mouse IgG1 |
| MOB-371YC | Recombinant Mouse Anti-IL1RL1 Detection Antibody (MOB-350YC) | ELISA | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-560-F(E) | Recombinant Anti-human IL1RL1 Antibody Fab Fragment | IF, WB, FuncS | Fab |
| MHH-560-F(E) | Recombinant Human Anti-human IL1RL1 Antibody Fab Fragment | WB, IHC, FuncS | Fab |
| PFBL-697 | Human Anti-IL1RL1 Recombinant Antibody (clone C2244); Fab Fragment | WB, IF, FuncS | Human Fab |
| TAB-222CT-F(E) | Mouse Anti-IL1RL1 Recombinant Antibody; Fab Fragment (TAB-222CT-F(E)) | ELISA, Inhib, FC | Mouse Fab |
| HPAB-0051-WJ-F(E) | Human Anti-IL1RL1 Recombinant Antibody; Fab Fragment (HPAB-0051-WJ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-560-S(P) | Recombinant Anti-human IL1RL1 Antibody scFv Fragment | FC, ELISA, FuncS | scFv |
| MHH-560-S(P) | Recombinant Human Anti-human IL1RL1 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| PSBL-697 | Human Anti-IL1RL1 Recombinant Antibody (clone C2244); scFv Fragment | WB, IF, FuncS | Human scFv |
| TAB-222CT-S(P) | Mouse Anti-IL1RL1 Recombinant Antibody; scFv Fragment (TAB-222CT-S(P)) | ELISA, Inhib, FC | Mouse scFv |
| HPAB-0051-WJ-S(P) | Human Anti-IL1RL1 Recombinant Antibody; scFv Fragment (HPAB-0051-WJ-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-225CT | Rabbit Anti-IL1RL1 Recombinant Antibody (TAB-225CT) | ELISA, FC, Inhibion | Rabbit IgG1 |
| TAB-225CT-S(P) | Rabbit Anti-IL1RL1 Recombinant Antibody; scFv Fragment (TAB-225CT-S(P)) | ELISA, FC, Inhibion | Rabbit scFv |
| TAB-225CT-F(E) | Rabbit Anti-IL1RL1 Recombinant Antibody; Fab Fragment (TAB-225CT-F(E)) | ELISA, FC, Inhibion | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-226CT | Human Anti-IL1RL1 Recombinant Antibody (TAB-226CT) | ELISA, FC, Inhibion | Humanized antibody |
| TAB-226CT-S(P) | Human Anti-IL1RL1 Recombinant Antibody; scFv Fragment (TAB-226CT-S(P)) | ELISA, FC, Inhibion | Humanized scFv |
| TAB-226CT-F(E) | Human Anti-IL1RL1 Recombinant Antibody; Fab Fragment (TAB-226CT-F(E)) | ELISA, FC, Inhibion | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1300CQ | Rat Anti-Il1rl1 Recombinant Antibody (NEUT-1300CQ) | FC, Block | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1301CQ | Rat Anti-Il1rl1 Recombinant Antibody (clone CBL595) | FC, CyTOF, ELISA, Neut | Rat IgG2b |
| NEUT-1302CQ | Mouse Anti-IL1RL1 Recombinant Antibody (NEUT-1302CQ) | WB, Neut | Mouse IgG2 |
| NEUT-1303CQ | Mouse Anti-IL1RL1 Recombinant Antibody (clone CBL171) | Neut, WB | Mouse IgG1 |
| NEUT-1304CQ | Mouse Anti-IL1RL1 Recombinant Antibody (clone CBL510) | WB, ELISA, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4255 | Rabbit Anti-IL1RL1 Recombinant Antibody (clone SI335DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1119 | Anti-IL1RL1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3508 | Anti-Human IL1RL1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC656 | Recombinant Anti-IL1RL1 Vesicular Antibody, EV Displayed (VS-0425-YC656) | ELISA, FC, Cell-uptake |
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