Human Anti-IL1RL1 (clone chKM1732) scFv-Fc Chimera (CAT#: VS-0425-FY2)

• Immunogen
• Human VEGF receptor Flt-1 as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• The chKM1732 antibody specifically reacts with human VEGF receptor Flt-1.

• Species Reactivity
• Human

• Clone
• chKM1732

• Applications
• Western Blot, Immunohistochemistry, Immunoprecipitation, ELISA, Neutralization

• Related Disease
• Chicken Egg Allergy and Asthma

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Interleukin 1 Receptor Like 1

• Gene ID
• 9173

• UniProt ID
• Q01638

• Long Name
• Interleukin 1 Receptor Like 1

• Sequence Similarities
• Belongs to the interleukin-1 receptor family.

• Cellular Localization
• Cell membrane, Secreted

• Post Translation Modifications
• Ubiquitinated at Lys-321 in a FBXL19-mediated manner; leading to proteasomal degradation.
  Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response.
  Glycosylation at Asn140, Asn54, Asn191, Asn95, Asn101, Asn232, Asn254, and Asn273
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect ILRL1_HUMAN (1948)
  Glycosylation from GlyGen 8 sites, 11 N-linked glycans (5 sites)

• Protein Refseq
• XP_006712902.1; XP_011510453.1; XP_054200480.1; XP_054200481.1; NP_001269337.1

• Function
• Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP.
  Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8.
  Possibly involved in helper T-cell function (Probable).
  Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages.

• HPAB-A1372-YJ
• Human Anti-IL1RL1 Recombinant Antibody (clone chKM1732)

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