Mouse Anti-ANXA2 scFv-Fc Chimera (VS-0625-FY2) (CAT#: VS-0625-FY2)

• Immunogen
• The immunogen used to generate the clone was a cytoskeleton preparation from HeLa cells.

• Host Species
• Mouse

• Type
• Mouse IgM, scFv-Fc

• Specificity
• The clone reacts with various cancers, including breast, colorectal, kidney, liver, and ovarian cancers. It preferentially binds to cells with an epithelial or intermediate epithelial phenotype.

• Species Reactivity
• Human

• Applications
• Flow Cytometry, Immunoprecipitation, ADCC, Cytotoxicity

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Cytotoxicity: 10 ug/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Annexin A2; Annexin II; Placental Anticoagulant Protein IV; Calpactin I Heavy Chain; Calpactin-1 Heavy Chain; Lipocortin II; Protein I; Annexin-2; ANX2L4; PAP-IV; CAL1H

• Gene ID
• 302

• UniProt ID
• P07355

• Long Name
• Annexin A2

• Sequence Similarities
• Belongs to the annexin family.

• Cellular Localization
• Secreted, extracellular space, extracellular matrix, basement membrane
  Melanosome

• Post Translation Modifications
• Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface
  ISGylated
  Ubiquitination at Lys49
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen

• Protein Refseq
• XP_016877581.1; XP_047288357.1; XP_047288358.1; XP_047288359.1; XP_047288360.1

• Function
• Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids.
  It binds two calcium ions with high affinity.
  May be involved in heat-stress response.
  Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.

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