Rabbit Anti-ITGA5 scFv-Fc Chimera (VS-0425-FY136) (CAT#: VS-0425-FY136)
Anti-ITGA5 scFv-FC is a recombinant single-chain variable fragment (scFv) fused to an Fc region, targeting the integrin alpha-5 (ITGA5) subunit. ITGA5 is involved in cell adhesion and extracellular matrix interactions, making this product potentially useful for research in cell migration, tissue engineering, and tumor biology. The scFv-FC format enhances stability and extends serum half-life, allowing for more effective applications in in vivo studies.
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Normal Tissue
RNA Expression
Figure 1 High expression in placenta
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/ihc_selected.jpg
Figure 2 Low expression in skeletal muscle
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_B_1_6_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_B_1_6_val_selected.jpg
Figure 3 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows distinct cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9008/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows distinct cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9008/ihc_selected.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_A_8_4.jpg
(Hepatocytes Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_A_8_4.jpg
Figure 5 Placenta
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Hofbauer cells Staining: Low Intensity: Moderate Quantity: <25% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_A_3_7.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Hofbauer cells Staining: Low Intensity: Moderate Quantity: <25% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_A_3_7.jpg
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1, HUVEC TERT2, TIME, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000161638-ITGA5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000161638-ITGA5
Specifications
- Immunogen
- The immunogen is eterodimeric alpha 5 Beta 1 Fc fusion protein.
- Host Species
- Rabbit
- Type
- Rabbit IgG, scFv-Fc
- Specificity
- Human ITGA5
- Species Reactivity
- Human
- Applications
- ELISA, Flow, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Blocking
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Alpha 5
- Gene ID
- 3678
- UniProt ID
- P08648
- Long Name
- Integrin Subunit Alpha 5
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell junction, Membrane
- Post Translation Modifications
- Proteolytic cleavage by PCSK5 mediates activation of the precursor.
- Protein Refseq
- NP_002196.4
- Function
- Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling.
ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling.
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1727z | Mouse Anti-ITGA5 Recombinant Antibody (clone 11B1) | WB, ELISA, FC, IHC | Mouse IgG2a |
| MOB-0506CT | Recombinant Mouse anti-Human ITGA5 Monoclonal antibody (DC50f) | FC | |
| HPAB-0398-WJ | Human Anti-ITGA5 Recombinant Antibody (HPAB-0398-WJ) | ELISA | Humanized IgG |
| HPAB-0399-WJ | Mouse Anti-ITGA5 Recombinant Antibody (HPAB-0399-WJ) | FC | Mouse IgG |
| VS3-CJ513 | Rabbit Anti-ITGA5 Recombinant Antibody (VS3-CJ513) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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