Rabbit Anti-ITGA5 scFv-Fc Chimera (VS-0425-FY136) (CAT#: VS-0425-FY136)

• Immunogen
• The immunogen is eterodimeric alpha 5 Beta 1 Fc fusion protein.

• Host Species
• Rabbit

• Type
• Rabbit IgG, scFv-Fc

• Specificity
• Human ITGA5

• Species Reactivity
• Human

• Applications
• ELISA, Flow, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Blocking

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Integrin Subunit Alpha 5

• Gene ID
• 3678

• UniProt ID
• P08648

• Long Name
• Integrin Subunit Alpha 5

• Sequence Similarities
• Belongs to the integrin alpha chain family.

• Cellular Localization
• Cell junction, Membrane

• Post Translation Modifications
• Proteolytic cleavage by PCSK5 mediates activation of the precursor.

• Protein Refseq
• NP_002196.4

• Function
• Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
  ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
  ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling.
  ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling.
  (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
  (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
  (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Select a product category from the dropdown menu below to view related products.