Rabbit Anti-JAK2 (phospho Y1007/Y1008) Monoclonal Antibody
CAT#: VS-0126-XL217
Recognizing dual-phosphorylated Y1007/1008 on JAK2, this rabbit monoclonal provides targeted detection of active kinases. It is a powerful tool for signaling research validated for WB, IHC, ICC, IP, and FC.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43870/1338_A2_1_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic and nuclear positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40820/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid tissue.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13089/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13089/29841_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13089/29841_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13089/29841_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13089/29841_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13089/29841_A_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Group enriched (ASC diff, HDLM-2, HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000096968-JAK2
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Specifications
- Host Species
- Rabbit
- Antibody Isotype
- Rabbit IgG
- Specificity
- JAK2 (Y1007/1008)
- Species Reactivity
- Human; Mouse; Rabbit
- Applications
- WB; IHC; ICC; IP; FC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Refinement of this monoclonal antibody is achieved through targeted capture on affinity resins, yielding a stable and potent final preparation.
- Concentration
- Lot specific
- Storage
- Store at -20˚C
- Shipping
- Ice Packs
Applications
- Application Notes
- WB: 1:500-1:2000
IHC: 1:50-1:200
ICC: 1:50-1:200
IP: 1:50
FC: 1:30
Target
- Alternative Names
- Janus kinase 2; JTK10; Tyrosine-protein kinase JAK2
- UniProt ID
- O60674
REVIEWS AND Q&AS
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Related Signaling Pathways
JAK-STAT Signaling Pathway
Related Diseases
Pancreatic Cancer
AGE-RAGE Signaling Pathway in Diabetic Complications
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| MOB-1854z | Mouse Anti-JAK2 Recombinant Antibody (clone 16B1) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
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| MRO-0880-CN | Recombinant Mouse Anti-JAK2 Monoclonal Antibody (6-D3) | WB, IF, IHC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY3687 | Anti-JAK2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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| VS-0525-XY3688 | Anti-Mouse JAK2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3689 | Anti-Rat JAK2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0126-XL6 | Anti-JAK2 (phospho Y1007/Y1008) Monoclonal Antibody | Phospho Antibodies for Cell Signaling Research |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0126-XL1208 | Rabbit Anti-JAK2 (phospho Y221) Antibody | Phospho Antibodies for Cell Signaling Research |
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