Anti-JAK2 Recombinant Antibody Products

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Anti-JAK2 Products

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For Research Use Only. Not For Clinical Use.

At Creative Biolabs, our mission is to supply top-tier anti-JAK2 antibodies crucial for biomedical research. Through strict adherence to high-quality benchmarks, we guarantee the efficacy of each product. By prioritizing precision and reliability, we equip researchers with robust tools that facilitate impactful scientific discoveries.

JAK2: A Crucial Enzyme in Blood Cancers and Inflammatory Diseases

Janus kinase 2 (JAK2) is a crucial enzyme in the JAK-STAT signaling pathway, which regulates key processes such as immune response, cell growth, and hematopoiesis. It is involved in transmitting signals from cytokine receptors to the nucleus, affecting gene expression. Mutations in JAK2, particularly the JAK2 V617F mutation, are associated with various hematologic disorders, including polycythemia vera, essential thrombocythemia, and myelofibrosis. As a result, JAK2 has become an important therapeutic target for the development of targeted treatments, particularly for blood cancers and inflammatory diseases.

Alternative Names

JTK10

Background

This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Anti-JAK2 rAb Products

Our focus is on delivering top-notch anti-JAK2 recombinant antibodies to fuel drug development research. Committed to advancing scientific progress, we offer reliable, high-performance products for target - oriented studies. We aim to provide trusted solutions that empower researchers to make significant breakthroughs.

Creative Quality Control

Our mission is to deliver superior antibody products. Leveraging cutting-edge technologies and stringent quality assurance processes, we develop antibodies with precision. These high - quality antibodies serve as essential tools for scientific research, particularly in driving progress towards more effective JAK2 - targeted therapies. Through this, we actively contribute to the advancement of medical science and the discovery of improved treatment modalities.

Customer Reviews

Excellent

Na**lie
Mouse Anti-JAK2 Recombinant Antibody (clone 3F10) (Cat#: MOB-0064F)

The antibody reliably detects JAK2 expression. Validated for IHC and IF, it precisely visualizes JAK2 in tissues and cells, aiding research on JAK2 - related signaling pathways and diseases like myeloproliferative disorders.

19/Feb/2024

Excellent

So**ia
Recombinant Mouse Anti-JAK2 Monoclonal Antibody (6-D3) (Cat#: MRO-0880-CN)

The product is a reliable option for detecting JAK2 expression in WB, IF, IHC, and FC. With high specificity and sensitivity, it’s suitable for researching JAK2 signaling, hematological disorders, and cancer, and is versatile for various molecular and cellular biology studies.

12/Aug/2023

rAb Production

Leveraging deep knowledge in expression vector design, cell line screening, and antibody purification, we offer end-to-end services spanning from gene synthesis to antibody production. Our dedicated team crafts high-quality, dependable solutions customized for biomedical research. By optimizing efficiency and maintaining consistency, we empower researchers to progress their projects, fueling scientific discoveries and therapeutic advancements.

Featured Anti-JAK2 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale recombinant antibody production.

Fig.4 Gram-scale recombinant antibody production.

rAb Modalities

Our portfolio encompasses a wide range of recombinant antibody formats, tailored to support basic research and drug discovery. Engineered to address the unique requirements of researchers, these antibodies deliver consistent quality and dependable performance. By offering flexible, customizable solutions, we strive to accelerate scientific innovation and foster progress in biomedicine, enabling researchers to make impactful discoveries.

Fig.5 Full Length Anti-JAK2 Recombinant Antibody Production and Modalities.

Drug Information Targeting JAK2

Table 1. Therapeutic approaches targeting JAK2 in clinical development.

Curious about our anti - JAK2 recombinant antibodies? Have questions? Contact us without delay. Our proficient team offers expert guidance and tailored solutions for your research. We're committed to ensuring your scientific work yields reliable results, with your success at the forefront.

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