Recombinant Anti-LAG3 Vesicular Antibody, EV Displayed (VS-0425-YC460)
CAT#: VS-0425-YC460
The Recombinant Anti-LAG3 Vesicular Antibody, EV Displayed (VS-0425-YC460) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LAG3-expressed cells or tissues. The LAG3 is a protein related to CD4, involved in lymphocyte activation and encoded across 8 exons.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human tonsil
High expression. RNA expression: 10.9 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_4_8_val_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebral cortex
Low expression. RNA expression: 0.7 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_B_9_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_7_4.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_4_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089692-LAG3
❮
❯
Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LAG3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Lymphocyte activating 3
- Biological Process
- Adaptive immunity, Immunity
- Introduction
- Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
- Alternative Names
- CD223
- Gene ID
- 3902
- UniProt ID
- P18627
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-0639CL-S(P) | Mouse Anti-LAG3 Recombinant Antibody; scFv Fragment (TAB-0639CL-S(P)) | ELISA, IHC | Mouse scFv |
| TAB-0640CL-S(P) | Mouse Anti-LAG3 Recombinant Antibody; scFv Fragment (TAB-0640CL-S(P)) | ELISA, IHC | Mouse scFv |
| TAB-0641CL-S(P) | Mouse Anti-LAG3 Recombinant Antibody; scFv Fragment (TAB-0641CL-S(P)) | ELISA, IHC | Mouse scFv |
| TAB-0638CL-F(E) | Mouse Anti-LAG3 Recombinant Antibody; Fab Fragment (TAB-0638CL-F(E)) | ELISA, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0690-CN | Human Anti-LAG3 Recombinant Antibody (HPAB-0690-CN) | WB, ELISA, FC, IHC | Human IgG1, κ |
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| HPAB-0692-CN | Human Anti-LAG3 Recombinant Antibody (HPAB-0692-CN) | WB, ELISA, FC, IHC | Human IgG4, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0186-YJ-F(E) | Human Anti-LAG3 Recombinant Antibody; Fab Fragment (HPAB-0186-YJ-F(E)) | FC, Block | Human Fab |
| HPAB-2358LY-F(E) | Human Anti-LAG3 Recombinant Antibody; Fab Fragment (HPAB-2358LY-F(E)) | ELISA | Humanized Fab |
| HPAB-2359LY-F(E) | Human Anti-LAG3 Recombinant Antibody; Fab Fragment (HPAB-2359LY-F(E)) | ELISA | Humanized Fab |
| HPAB-2360LY-F(E) | Human Anti-LAG3 Recombinant Antibody; Fab Fragment (HPAB-2360LY-F(E)) | ELISA | Humanized Fab |
| HPAB-2361LY-F(E) | Human Anti-LAG3 Recombinant Antibody; Fab Fragment (HPAB-2361LY-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2385LY-S(P) | Human Anti-LAG3 Recombinant Antibody; scFv Fragment (HPAB-2385LY-S(P)) | ELISA, FC | Humanized scfv |
| HPAB-2386LY-S(P) | Human Anti-LAG3 Recombinant Antibody; scFv Fragment (HPAB-2386LY-S(P)) | ELISA, FC | Humanized scfv |
| HPAB-2387LY-S(P) | Human Anti-LAG3 Recombinant Antibody; scFv Fragment (HPAB-2387LY-S(P)) | ELISA, FC | Humanized scfv |
| HPAB-2388LY-S(P) | Human Anti-LAG3 Recombinant Antibody; scFv Fragment (HPAB-2388LY-S(P)) | ELISA, FC | Humanized scfv |
| HPAB-2389LY-S(P) | Human Anti-LAG3 Recombinant Antibody; scFv Fragment (HPAB-2389LY-S(P)) | ELISA, FC | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY4 | Human Anti-LAG3 (clone F7) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
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