Can this antibody neutralize Lag3?

Yes, this Recombinant Rat Anti-Lag3 Antibody (clone C9B7W) binds specifically to Mouse CD223 (Lag3) and can neutralize its bioactivity. It is validated for Neutralization, IP, FC, and Functional Studies.

What is the host and isotype of this antibody?

This is a Rat IgG1, kappa monoclonal antibody. It is a recombinant antibody produced in a mouse expression system. It specifically recognizes Mouse CD223 and is affinity purified.

Recombinant Rat Anti-Lag3 Antibody (C9B7W)

CAT#: NEUT-1676CQ

This antibody is a rat monoclonal antibody that binds specifically to mouse CD223, and it can neutralize the bioactivity of mouse CD223.

Gene Expression

Normal Tissue Figure 1 IHC staining of human tonsil

High expression. RNA expression: 10.9 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_4_8_val_selected.jpg

Normal Tissue Figure 2 IHC staining of human cerebral cortex

Low expression. RNA expression: 0.7 nTPM

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_B_9_5_val_selected.jpg

Normal Tissue Figure 3 Colon

Glandular cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_8_3.jpg

Normal Tissue Figure 4 Liver

Hepatocytes
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_7_4.jpg

Normal Tissue Figure 5 Testis

Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_4_6.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089692-LAG3

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Specifications

Host Species
Rat

Type
IgG1, κ

Specificity
Recognizes Mouse CD223

Species Reactivity
Mouse

Clone
C9B7W

Applications
Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Functional Studies; Flow Cytometry; Immunoprecipitation; Neutralization

Conjugate
Unconjugated

Product Property

Purification
Affinity chromatography

Purity
>95% as determined by analysis by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze-thaw cycles.

Target

Alternative Names
Lag3; lymphocyte-activation gene 3; Ly66; CD223; LAG-3

Gene ID
16768

UniProt ID
Q61790

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Breast cancer biomarkers at key points during disease progression

Potent Lag3 Neutralization

This Recombinant Rat Anti-Lag3 Antibody (clone C9B7W) is excellent for functional studies. We used it to neutralize the bioactivity of Mouse CD223 (Lag3) in T cell activation assays. It bound specifically and produced the expected biological effect. Highly recommended for immunology research.

Great Flow Cytometry Antibody

We also used this antibody for Flow Cytometry to stain mouse lymphocytes. It provided clear separation of Lag3-positive cells. The affinity chromatography purification ensures a clean product with>95% purity. We store it at -20°C to maintain its functional integrity.

Q&As

Can this antibody neutralize Lag3?

A: Yes, this Recombinant Rat Anti-Lag3 Antibody (clone C9B7W) binds specifically to Mouse CD223 (Lag3) and can neutralize its bioactivity. It is validated for Neutralization, IP, FC, and Functional Studies.
What is the host and isotype of this antibody?

A: This is a Rat IgG1, kappa monoclonal antibody. It is a recombinant antibody produced in a mouse expression system. It specifically recognizes Mouse CD223 and is affinity purified.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - NEUT-1676CQ.pdf

MSDS

MSDS - NEUT-1676CQ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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