Human Anti-LAG3 (clone SRP1449-B03) scFv-Fc Chimera (CAT#: VS-0325-FY9)
The Anti-LAG3 scFv-Fc Antibody targets the LAG3 molecule, an immune checkpoint receptor. It offers high specificity and can be used to study the role of LAG3 in immune responses. This antibody is suitable for use in immunology and cancer research.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human tonsil
(High expression. RNA expression: 10.9 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_4_8_val_selected.jpg
(High expression. RNA expression: 10.9 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_4_8_val_selected.jpg
Figure 2 IHC staining of human cerebral cortex
(Low expression. RNA expression: 0.7 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_B_9_5_val_selected.jpg
(Low expression. RNA expression: 0.7 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_B_9_5_val_selected.jpg
Figure 3 Colon
(Glandular cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_8_3.jpg
(Glandular cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_8_3.jpg
Figure 4 Liver
(Hepatocytes
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_7_4.jpg
(Hepatocytes
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_7_4.jpg
Figure 5 Testis
(Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_4_6.jpg
(Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2301/5962_A_4_6.jpg
Figure 6 Lymph node
(Germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_7_8.jpg
(Germinal center cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13967/30401_A_7_8.jpg
Figure 7 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089692-LAG3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089692-LAG3
Specifications
- Immunogen
- Balb/C mice were immunized with the extracellular domain of human LAG3 fused with human Fc.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The antibody specifically binds to human LAG3
- Species Reactivity
- Human
- Clone
- SRP1449-B03
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- CD223
- Gene ID
- 3902
- UniProt ID
- P18627
- Long Name
- Lymphocyte-activation gene 3
- Sequence Similarities
- Belongs to the LAG3 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn188, Asn250, Asn256, and Asn343
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- NP_001401105.1; NP_001401106.1; NP_002277.4
- Function
- Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, 7805750, 8647185).
Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).
FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).
Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity).
Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0367CL | Anti-Human LAG3 Recombinant Antibody (TSR-033) | FC, FuncS, Block | Human antibody |
| TAB-0367CL-S(P) | Anti-Human LAG3 Recombinant Antibody scFv Fragment (TSR-033) | ELISA, WB | Human antibody |
| TAB-0367CL-F(E) | Anti-Human LAG3 Recombinant Antibody Fab Fragment (TSR-033) | ELISA, WB | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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