Anti-Human LAG3 Recombinant Antibody (TSR-033) (CAT#: TAB-0367CL)

This LAG3-specific antibody demonstrates a potent and durable anti-tumor activity in syngeneic tumor models. It can be used for immunotherapy.


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FC

Figure 1 TSR-033 binds with high affinity to human and cyno LAG-3.

Figure 1 TSR-033 binds with high affinity to human and cyno LAG-3.

TSR-033 binds human and cyno LAG-3 expressed on the surface of CHO-S cells, but not mouse LAG-3, as assessed and flow cytometry.

Ghosh, S., Sharma, G., Travers, J., Kumar, S., Choi, J., Jun, H. T., ... & Jenkins, D. (2019). TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo. Molecular cancer therapeutics, 18(3), 632-641.

FuncS

Figure 2 TSR-033 amplifies T cell effector function, particularly in combination with anti-PD-1.

Figure 2 TSR-033 amplifies T cell effector function, particularly in combination with anti-PD-1.

The functional activity of TSR-033 was evaluated in an MLR assay, in which primary human CD4 T cells were mixed with monocyte-derived dendritic cells from a different donor. The ability of TSR-033 and TSR-042 to induce IL-2 from human PBMCs (n=5 donors) stimulated with 100 ng/mL SEB for 3 days was assessed. Data are representative of at least two separate occasions.

Ghosh, S., Sharma, G., Travers, J., Kumar, S., Choi, J., Jun, H. T., ... & Jenkins, D. (2019). TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo. Molecular cancer therapeutics, 18(3), 632-641.

Block

Figure 3 Dual blockade of LAG-3 and PD-1 using TSR-033 and TSR-042 improves therapeutic efficacy and T cell stimulation in a humanized NSCLC tumor mouse model.

Figure 3 Dual blockade of LAG-3 and PD-1 using TSR-033 and TSR-042 improves therapeutic efficacy and T cell stimulation in a humanized NSCLC tumor mouse model.

The combination of TSR-033 with TSR-042 has an additive effect (CDI=1.001) on restricting tumor growth in HuNOG-EXL mice inoculated with A549 cells. Mice were randomized at tumor volumes of 80-120 mm³, followed by administration of the indicated regimens (Materials and methods). Tumor growth inhibition at termination for each treatment arm is indicated in parentheses.

Ghosh, S., Sharma, G., Travers, J., Kumar, S., Choi, J., Jun, H. T., ... & Jenkins, D. (2019). TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo. Molecular cancer therapeutics, 18(3), 632-641.


Specifications

  • Immunogen
  • Human LAG-3 ECD (for panning)
  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • TSR-033
  • Applications
  • FC, FuncS, Block
  • Related Disease
  • Tumor

Applications

  • Application Notes
  • The LAG-3 antibody has been reported in applications of Flow Cytometry, Functional Assay, Blocking.

Target

  • Alternative Names
  • LAG3; lymphocyte-activation gene 3; CD223; lymphocyte activation gene 3 protein

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Human Antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1675CQ Recombinant Mouse Anti-LAG3 Antibody (11E3) WB, Neut, ELISA, IF, IHC, IP IgG1
NEUT-1676CQ Recombinant Rat Anti-Lag3 Antibody (C9B7W) ELISA, FuncS, FC, IP, Neut IgG1, κ

Rabbit Monoclonal Antibody

Recombinant Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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