Human Anti-LAG3 (clone F7) scFv-Fc Chimera (CAT#: VS-0125-FY4)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• F7

• Applications
• ELISA, Flow Cytometry

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The anti-LAG3 scFv-Fc combines the features of a single-chain variable fragment (scFv) and the Fc region, exhibiting strong targeting ability and sustained biological activity. By targeting LAG3, this antibody can reactivate tumor-infiltrating lymphocytes, promoting the immune system's recognition and attack on tumor cells. This therapy holds promise for improving treatment outcomes in patients who do not respond to current immune checkpoint therapies and may become an important complement in anti-tumor immunotherapy.

• Alternative Names
• CD223

• Gene ID
• 3902

• UniProt ID
• P18627

• Sequence Similarities
• Belongs to the LAG3 family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn188, Asn250, Asn256, and Asn343
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 4 sites

• Protein Refseq
• NP_001401105.1; NP_001401106.1; NP_002277.4

• Function
• Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells.
  Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity).
  FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity).
  Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity).
  May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity).
  Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• VS-0723-CJ22
• Human Anti-LAG3 Recombinant Antibody (clone F7)

Select a product category from the dropdown menu below to view related products.