Recombinant Anti-NTRK2 Vesicular Antibody, EV Displayed (VS-0425-YC548)
CAT#: VS-0425-YC548
The Recombinant Anti-NTRK2 Vesicular Antibody, EV Displayed (VS-0425-YC548) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to NTRK2-expressed cells or tissues. NTRK2 is a neurotrophic receptor kinase, activating MAPK pathways for cell differentiation. Mutations are linked to obesity and mood disorders.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, HaCaT, RPTEC TERT1, SH-SY5Y, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
❮
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- NTRK2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Neurotrophic receptor tyrosine kinase 2
- Biological Process
- Differentiation, Neurogenesis
- Molecular Function
- Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
- Alternative Names
- TRKB
- Gene ID
- 4915
- UniProt ID
- Q16620
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Related Diseases
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
| TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-171CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (18H6) | ELISA, FC | |
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| TAB-173CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (6B72C5) | ELISA, WB, IP | |
| TAB-174CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (5G5D2B5) | ELISA, WB, IP | |
| TAB-175CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (17D11) | ELISA, FC, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-178CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (A2) | ELISA, FC | Humanized antibody |
| TAB-179CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (RN1026A) | ELISA, FC | Humanized antibody |
| TAB-177CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-178CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (A2) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2509 | Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) | WB, IHC, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-095CN | Human Anti-NTRK2 Recombinant Antibody (NS-095CN) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0663-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0663-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0664-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0664-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0665-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0665-CN-S(P)) | ELISA, Neut | Human scFv |
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| HPAB-AP762-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12); scFv Fragment | Agonist, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP761-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4A6); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP762-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP763-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone C1); Fab Fragment | Agonist, FuncS | Humanized Fab |
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| HPAB-AP765-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-15); Fab Fragment | Agonist | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5019 | Anti-NTRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5020 | Anti-Mouse NTRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5021 | Anti-Rat NTRK2 Immunohistochemistry Kit | IHC |
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