Human Anti-NTRK2 (clone 7-F1) scFv-Fc Chimera
CAT#: VS-0325-FY99
The anti-TrkB scFv-Fc antibody targets TrkB, a receptor tyrosine kinase involved in neuronal survival and development. It has potential therapeutic applications in neurological disorders, such as depression and neurodegenerative diseases. The scFv-Fc format enhances its stability and bioavailability, making it suitable for prolonged therapeutic use.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, HaCaT, RPTEC TERT1, SH-SY5Y, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human NTRK2
- Species Reactivity
- Human
- Clone
- 7-F1
- Applications
- Immunoassay
- Related Disease
- Neurodegenerative disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Neurotrophic Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase Receptor Type 2; Tropomyosin-Related Kinase B; EC 2.7.10.1; GP145-TrkB; Trk-B; TRKB; Neurotrophic Tyrosine Kinase, Receptor, Type 2
- Gene ID
- 4915
- UniProt ID
- Q16620
- Long Name
- Neurotrophic Receptor Tyrosine Kinase 2
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Endosome; Membrane; Synapse
- Function
- NTRK2, also known as TrkB, is a tyrosine kinase receptor that mediates the biological effects of brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5). Upon ligand binding, NTRK2 activates intracellular signaling pathways that promote neuronal survival, differentiation, and synaptic plasticity. It plays critical roles in the development and function of the nervous system, influencing processes such as learning, memory, and mood regulation.
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 7-F1"
- CAT
- Product Name
See other products for "NTRK2"
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-0662-CN-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-0662-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0663-CN-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-0663-CN-F(E)) | ELISA, Neut | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-AP762-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4B12) | FuncS | Humanized IgG |
| HPAB-AP763-YC | Human Anti-NTRK2 Recombinant Antibody (clone C1) | FuncS | Humanized IgG |
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