Anti-Human NTRK2 Recombinant Antibody (5G5D2B5) (CAT#: TAB-174CQ)
The monoclonal antibody binds to a particular part of tropomyosin-related kinase B receptor (TrkB) and can be potentially used in the treatment of cancer, pain, anorexia, anorexia nervosa and cachexia.
Specific Inquiry
WB
Figure 1 Internalization of TrkB studied by Western blot of PC12-TrkB cell extracts treated with or without BDNF in the presence or absence of scFv 5G5D2B5 or anti-TrkB Abs.
The presence of scFv 5G5D2B5 increased the internalization induced by BDNF. Results are expressed as average percentage of internalization (% I)±SD; **, p<0.01; ***, p<0.001, one-way ANOVA.
FuncS
Figure 2 7-days cumulative food intake (FI) in rats which received 1 μg of scFv 5G5D2B5 (upper curve) (n=9) or BSA (lower curve) (n=7) i.c.v. into the third ventricle. The injection of scFv 5G5D2B5 increased FI compared to controls. h=time in hours.
FuncS
Figure 3 Body weight change in g (y-axis) during 7 days after i.c.v. administration of scFv 5G5D2B5 or BSA as control. scFv 5G5D2B5 (---▴---) induced an increase in body weight compared with rats which received BSA (-▪-). Data presented as mean±sem. *:p<0.05, two-way ANOVA Bon Ferroni post-hoc test. d=time in days.
Specifications
- Immunogen
- A peptide corresponding to the first loop of the D5 domain of the TrkB(B1 peptide, TITFLESPTSDHHWCIPFTV)
- Host Species
- Rat
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 5G5D2B5
- Applications
- FuncS, WB
- Related Disease
- Cancer
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Western Blot.
Target
- Alternative Names
- NTRK2; Neurotrophic receptor tyrosine kinase 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B
- Gene ID
- 4915
- UniProt ID
- Q16620
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
| TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
| TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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