The monoclonal antibody binds to a particular part of tropomyosin-related kinase B receptor (TrkB) and can be potentially used in the treatment of cancer, pain, anorexia, anorexia nervosa and cachexia.
Figure 1 Internalization of TrkB studied by Western blot of PC12-TrkB cell extracts treated with or without BDNF in the presence or absence of scFv 5G5D2B5 or anti-TrkB Abs.
The presence of scFv 5G5D2B5 increased the internalization induced by BDNF. Results are expressed as average percentage of internalization (% I)±SD; **, p<0.01; ***, p<0.001, one-way ANOVA.
Figure 2 7-days cumulative food intake (FI) in rats which received 1 μg of scFv 5G5D2B5 (upper curve) (n=9) or BSA (lower curve) (n=7) i.c.v. into the third ventricle. The injection of scFv 5G5D2B5 increased FI compared to controls. h=time in hours.
Figure 3 Body weight change in g (y-axis) during 7 days after i.c.v. administration of scFv 5G5D2B5 or BSA as control. scFv 5G5D2B5 (---▴---) induced an increase in body weight compared with rats which received BSA (-▪-). Data presented as mean±sem. *:p<0.05, two-way ANOVA Bon Ferroni post-hoc test. d=time in days.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-171CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (18H6) | ELISA, FC | |
TAB-172CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (38B8) | ELISA, FC | |
TAB-173CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (6B72C5) | ELISA, WB, IP | |
TAB-174CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (5G5D2B5) | ELISA, WB, IP | |
TAB-175CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (17D11) | ELISA, FC, WB |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-177CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C2) | ELISA, FC | Humanized antibody |
TAB-178CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (A2) | ELISA, FC | Humanized antibody |
TAB-179CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (RN1026A) | ELISA, FC | Humanized antibody |
TAB-177CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C2) | ELISA, FC | Humanized antibody |
TAB-178CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (A2) | ELISA, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2509 | Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) | WB, IHC, IP | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NS-095CN | Human Anti-NTRK2 Recombinant Antibody (NS-095CN) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-458 | Mouse Anti-NTRK2 Recombinant Antibody (clone AB20); scFv Fragment | ELISA, FC, IF, Agonist | Mouse scFv |
HPAB-N0197-YC-S(P) | Mouse Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-N0197-YC-S(P)) | FuncS, WB | Mouse scFv |
HPAB-N0198-YC-S(P) | Mouse Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-N0198-YC-S(P)) | FuncS | Mouse scFv |
HPAB-N0199-YC-S(P) | Mouse Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-N0199-YC-S(P)) | FuncS | Mouse scFv |
HPAB-N0200-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-N0200-YC-S(P)) | FuncS, WB | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0197-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0197-YC-F(E)) | FuncS, WB | Mouse Fab |
HPAB-N0198-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0198-YC-F(E)) | FuncS | Mouse Fab |
HPAB-N0199-YC-F(E) | Mouse Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0199-YC-F(E)) | FuncS | Mouse Fab |
HPAB-N0200-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0200-YC-F(E)) | FuncS, WB | Humanized Fab |
HPAB-N0201-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody; Fab Fragment (HPAB-N0201-YC-F(E)) | FuncS | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP761-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4A6) | FuncS | Humanized IgG |
HPAB-AP762-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4B12) | FuncS | Humanized IgG |
HPAB-AP763-YC | Human Anti-NTRK2 Recombinant Antibody (clone C1) | FuncS | Humanized IgG |
HPAB-AP764-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-17) | Agonist | Humanized IgG |
HPAB-AP765-YC | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-15) | Agonist | Humanized IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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