Anti-Human NTRK2 Recombinant Antibody (5G5D2B5) (CAT#: TAB-174CQ)

The monoclonal antibody binds to a particular part of tropomyosin-related kinase B receptor (TrkB) and can be potentially used in the treatment of cancer, pain, anorexia, anorexia nervosa and cachexia.


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WB

Figure 1 Internalization of TrkB studied by Western blot of PC12-TrkB cell extracts treated with or without BDNF in the presence or absence of scFv 5G5D2B5 or anti-TrkB Abs.

Figure 1 Internalization of TrkB studied by Western blot of PC12-TrkB cell extracts treated with or without BDNF in the presence or absence of scFv 5G5D2B5 or anti-TrkB Abs.

The presence of scFv 5G5D2B5 increased the internalization induced by BDNF. Results are expressed as average percentage of internalization (% I)±SD; **, p<0.01; ***, p<0.001, one-way ANOVA.

FuncS

Figure 2 7-days cumulative food intake (FI) in rats which received 1 μg of scFv 5G5D2B5 (upper curve) (n=9) or BSA (lower curve) (n=7) i.c.v. into the third ventricle. The injection of scFv 5G5D2B5 increased FI compared to controls. h=time in hours.

Figure 2 7-days cumulative food intake (FI) in rats which received 1 μg of scFv 5G5D2B5 (upper curve) (n=9) or BSA (lower curve) (n=7) i.c.v. into the third ventricle. The injection of scFv 5G5D2B5 increased FI compared to controls. h=time in hours.

FuncS

Figure 3 Body weight change in g (y-axis) during 7 days after i.c.v. administration of scFv 5G5D2B5 or BSA as control. scFv 5G5D2B5 (---▴---) induced an increase in body weight compared with rats which received BSA (-▪-). Data presented as mean±sem. *:p<0.05, two-way ANOVA Bon Ferroni post-hoc test. d=time in days.

Figure 3 Body weight change in g (y-axis) during 7 days after i.c.v. administration of scFv 5G5D2B5 or BSA as control. scFv 5G5D2B5 (---▴---) induced an increase in body weight compared with rats which received BSA (-▪-). Data presented as mean±sem. *:p<0.05, two-way ANOVA Bon Ferroni post-hoc test. d=time in days.


Specifications

  • Immunogen
  • A peptide corresponding to the first loop of the D5 domain of the TrkB(B1 peptide, TITFLESPTSDHHWCIPFTV)
  • Host Species
  • Rat
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • 5G5D2B5
  • Applications
  • FuncS, WB
  • Related Disease
  • Cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay, Western Blot.

Target

  • Alternative Names
  • NTRK2; Neurotrophic receptor tyrosine kinase 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Human Antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2509 Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) WB, IHC, IP IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-095CN Human Anti-NTRK2 Recombinant Antibody (NS-095CN) ELISA Human IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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