Anti-Human NTRK2 Recombinant Antibody (5G5D2B5)
CAT#: TAB-174CQ
The monoclonal antibody binds to a particular part of tropomyosin-related kinase B receptor (TrkB) and can be potentially used in the treatment of cancer, pain, anorexia, anorexia nervosa and cachexia.
Published Data
Gene Expression
WB
Figure 1 Internalization of TrkB studied by Western blot of PC12-TrkB cell extracts treated with or without BDNF in the presence or absence of scFv 5G5D2B5 or anti-TrkB Abs.
The presence of scFv 5G5D2B5 increased the internalization induced by BDNF. Results are expressed as average percentage of internalization (% I)±SD; **, p<0.01; ***, p<0.001, one-way ANOVA.
FuncS
Figure 2 7-days cumulative food intake (FI) in rats which received 1 μg of scFv 5G5D2B5 (upper curve) (n=9) or BSA (lower curve) (n=7) i.c.v. into the third ventricle. The injection of scFv 5G5D2B5 increased FI compared to controls. h=time in hours.
FuncS
Figure 3 Body weight change in g (y-axis) during 7 days after i.c.v. administration of scFv 5G5D2B5 or BSA as control. scFv 5G5D2B5 (---▴---) induced an increase in body weight compared with rats which received BSA (-▪-). Data presented as mean±sem. *:p<0.05, two-way ANOVA Bon Ferroni post-hoc test. d=time in days.
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, HaCaT, RPTEC TERT1, SH-SY5Y, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
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Specifications
- Immunogen
- A peptide corresponding to the first loop of the D5 domain of the TrkB(B1 peptide, TITFLESPTSDHHWCIPFTV)
- Host Species
- Rat
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 5G5D2B5
- Applications
- FuncS, WB
- Related Disease
- Cancer
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Western Blot.
Target
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 5G5D2B5"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2510z | Mouse Anti-NTRK2 Recombinant Antibody (clone 20A1) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0842MZ | Recombinant Mouse Anti-Human NTRK2 Antibody (clone 3D12) | WB | Mouse antibody |
| VS3-FY1072 | Recombinant Rabbit Anti-Ntrk2 Antibody (clone R03-4C7) | WB, IHC-P, IP | Rabbit IgG |
| VS3-FY1073 | Recombinant Rabbit Anti-NTRK2 (phospho Tyr516) Antibody (clone R04-3D9) | WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-171CQ | Anti-Human NTRK2 Recombinant Antibody (18H6) | ELISA, FC | |
| TAB-172CQ | Anti-Human NTRK2 Recombinant Antibody (38B8) | ELISA, FC | |
| TAB-173CQ | Anti-Human NTRK2 Recombinant Antibody (6B72C5) | ELISA, WB, IP | |
| TAB-175CQ | Anti-Human NTRK2 Recombinant Antibody (17D11) | ELISA, FC, WB | |
| TAB-176CQ | Anti-Human NTRK2 Recombinant Antibody (29D7) | WB, IF, ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177CQ | Anti-Human NTRK2 Recombinant Antibody (C2) | Agonist, FuncS | Humanized antibody |
| TAB-178CQ | Anti-Human NTRK2 Recombinant Antibody (A2) | ELISA, FC | Humanized antibody |
| TAB-179CQ | Anti-Human NTRK2 Recombinant Antibody (RN1026A) | ELISA, FC | Humanized antibody |
| TAB-177CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-178CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (A2) | ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
| TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
| TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2509 | Hi-Affi™ Recombinant Rabbit Anti-NTRK2 Monoclonal Antibody (DS2509AB) | WB, IHC, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-095CN | Human Anti-NTRK2 Recombinant Antibody (NS-095CN) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-095CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (NS-095CN-S(P)) | ELISA | Human scFv |
| HPAB-0662-CN-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-0662-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-J0197-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-J0197-YC-S(P)) | ELISA | Human scFv |
| HPAB-J0198-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-J0198-YC-S(P)) | ELISA | Human scFv |
| HPAB-J0199-YC-S(P) | Human Anti-NTRK2 Recombinant Antibody; scFv Fragment (HPAB-J0199-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP761-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4A6); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP762-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP763-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone C1); Fab Fragment | Agonist, FuncS | Humanized Fab |
| HPAB-AP764-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-17); Fab Fragment | Agonist | Humanized Fab |
| HPAB-AP765-YC-F(E) | Human Anti-NTRK2 Recombinant Antibody (clone 4B12-15); Fab Fragment | Agonist | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY99 | Human Anti-NTRK2 (clone 7-F1) scFv-Fc Chimera | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC548 | Recombinant Anti-NTRK2 Vesicular Antibody, EV Displayed (VS-0425-YC548) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5019 | Anti-NTRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5020 | Anti-Mouse NTRK2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5021 | Anti-Rat NTRK2 Immunohistochemistry Kit | IHC |
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