Recombinant Rabbit Anti-STAT6 Antibody (clone R07-1H8)
CAT#: VS3-FY1402
This product is a recombinant rabbit antibody that recognizes STAT6. This antibody has been reported for use in Western Blot. The clone R07-1H8 is specific for human, mouse, rat, Hamster STAT6. The antigen is synthetic peptide of human stat6.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/27_A4_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong cytoplasmic and nuclear positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/7497_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/7497_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/7497_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/7497_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1861/7497_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166888-STAT6/subcellular
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WB
Figure 1. Recombinant Rabbit Anti-STAT6 Antibody (clone R07-1H8) in WB.
Western Blot analysis of STAT6 in Jurkat, CHO-K1, Hela lysates using STAT6 Antibody.
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Specifications
- Immunogen
- Synthetic peptide of human STAT6.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat, Hamster STAT6
- Species Reactivity
- Human, Mouse, Rat, Hamster
- Clone
- R07-1H8
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 94 kDa; Observed MW: 110 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- STAT6; Signal transducer and activator of transcription 6; IL-4 Stat
- Gene ID
- 6778
- UniProt ID
- P42226
- Sequence Similarities
- Belongs to the transcription factor STAT family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300).
Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity).
Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.
- Protein Refseq
- NP_001171549.1; NP_001171550.1; NP_001171551.1
- Function
- Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
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Related Diseases
Endometrial Cancer
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Pancreatic Cancer
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Related Signaling Pathways
MAPK Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "STAT6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0567MZ | Chicken Anti-STAT6 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3430 | Hi-Affi™ Recombinant Rabbit Anti-STAT6 Monoclonal Antibody (DS3430AB) | FC, ICC, IP, WB | IgG |
| MOR-4713 | Hi-Affi™ Recombinant Rabbit Anti-STAT6 Monoclonal Antibody (TH227DS) | WB, IF, ICC, IHC-P, FC, ChIP, ELISA | IgG |
| MOR-4745 | Hi-Affi™ Recombinant Rabbit Anti-STAT6 Monoclonal Antibody (TH259DS) | WB, IF, ICC, IHC-P, FC, ChIP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1443-CN | Recombinant Rabbit Anti-STAT6 Monoclonal Antibody (CBACN-534) | WB, IF, IHC, IP | Rabbit IgG |
| MRO-1444-CN | Recombinant Rabbit Anti-STAT6 Monoclonal Antibody (CBACN-535) | WB, IF, IHC, IP | Rabbit IgG |
| MRO-2202-CN | Rabbit Anti-STAT6 Polyclonal Antibody (MRO-2202-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-118R | Mouse Anti-STAT6 Recombinant Antibody (ZG-118R) | WB, ELISA, IF | Mouse IgG |
| ZG-0096U | Rabbit Anti-STAT6 Recombinant Antibody (clone 2F10) | ELISA, WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC633 | AbPlus™ Anti-STAT6 Magnetic Beads (VS-0724-YC633) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2198 | Anti-STAT6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6961 | Anti-Mouse STAT6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6960 | Anti-Human STAT6 Immunohistochemistry Kit | IHC |
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