Recombinant Anti-TLR2 Vesicular Antibody, EV Displayed (VS-0425-YC654)
CAT#: VS-0425-YC654
The Recombinant Anti-TLR2 Vesicular Antibody, EV Displayed (VS-0425-YC654) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TLR2-expressed cells or tissues. TLR2 is a critical protein in the Toll-like receptor family, essential for pathogen recognition and innate immunity activation. It forms heterodimers with other TLRs to identify pathogen-associated molecular patterns, modulating inflammatory responses and promoting apoptosis in response to bacterial lipoproteins.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60231/1551_D10_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HL-60, HSkMC, hTCEpi, NB-4, RPTEC TERT1, RT4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137462-TLR2
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TLR2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Toll like receptor 2
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Nucleoplasm, Vesicles, Cytosol
- Introduction
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- Alternative Names
- CD282, TIL4
- Gene ID
- 7097
- UniProt ID
- O60603
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-YC654. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TLR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1393z | Mouse Anti-TLR2 Recombinant Antibody (clone 23C7) | WB, FC, IF, IHC, FuncS | Mouse IgG2a, κ |
| MOB-0271MC | Rabbit Anti-TLR2 Antibody | WB | |
| HPAB-0052-YC | Human Anti-TLR2 Recombinant Antibody (HPAB-0052-YC) | Neut | Humanized IgG |
| VS-0723-WK9 | Human Anti-TLR2 Recombinant Antibody (clone Tomaralimab) | FC | Chimeric (mouse/human) IgG4 |
| VS13-YC1161 | Rabbit Anti-Tlr2 Recombinant Antibody (VS13-YC1161) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B030(A) | Recombinant Anti-TLR2 Intrabody [(D-Arg)9] | ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B030(G) | Recombinant Anti-TLR2 Intrabody [+36 GFP] | ELISA, WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B030(T) | Recombinant Anti-TLR2 Intrabody [Tat] | IF, FC, WB, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268CQ | Mouse Anti-TLR2 Recombinant Antibody (TAB-268CQ) | FC, IHC, IF, WB | Mouse IgG1, κ |
| TAB-268CQ-S(P) | Mouse Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-268CQ-S(P)) | ELISA, FC, WB, IP | Mouse scFv |
| TAB-268CQ-F(E) | Mouse Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-268CQ-F(E)) | ELISA, FC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-269CQ | Human Anti-TLR2 Recombinant Antibody (TAB-269CQ) | ELISA, FC, FuncS, IP, Inhib | Humanized IgG1, κ |
| TAB-269CQ-S(P) | Human Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-269CQ-S(P)) | ELISA, FC, WB, IP | Humanized scFv |
| TAB-269CQ-F(E) | Human Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-269CQ-F(E)) | ELISA, FC, WB, IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0588MZ | Chicken Anti-TLR2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2031CQ | Mouse Anti-TLR2 Recombinant Antibody (clone TL2.1) | FC, IP, Block, IHC, WB | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2032CQ | Mouse Anti-Tlr2 Recombinant Antibody (NEUT-2032CQ) | Neut | Mouse IgG2a |
| NEUT-2033CQ | Human Anti-TLR2 Recombinant Antibody (NEUT-2033CQ) | Neut, FC | Human IgA2 |
| NEUT-2034CQ | Mouse Anti-TLR2 Recombinant Antibody (clone CBL627) | FC, CyTOF, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3585 | Rabbit Anti-TLR2 Recombinant Antibody (clone DS3585AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-YC-S(P) | Human Anti-TLR2 Recombinant Antibody; scFv Fragment (HPAB-0052-YC-S(P)) | Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-YC-F(E) | Human Anti-TLR2 Recombinant Antibody; Fab Fragment (HPAB-0052-YC-F(E)) | Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY254 | AbPlus™ Anti-TLR2 Magnetic Beads (VS-0424-XY254) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY212 | CytoStream™ Mouse Anti-TLR2 Recombinant Antibody (clone 11G7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY29 | Human Anti-TLR2 scFv-Fc Chimera (VS-0425-FY29) | FC, Inhib, ELISA | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7301 | Anti-TLR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7302 | Anti-Human TLR2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: ELISA, WB, BLI, SPR
![Figure 2 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in HPLC](https://img.creativebiolabs.net/productimages/COA-TAB-1611CL-F(E)-2.png)
Application: Depletion, FuncS
Application: WB, ELISA, FC, IHC, IP
Application: WB, ELISA, IF
Application: WB, IHC, ELISA, FC
Application: ELISA, FC, IF, WB
Application: WB, ELISA, Neut, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
