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TLR2
Anti-TLR2 Recombinant Antibody Products
- AbPlus™ Anti-TLR2 Magnetic Beads (VS-0424-XY254) (VS-0424-XY254)
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- Target: TLR2
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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- Mouse Anti-TLR2 Recombinant Antibody (clone CBL627) (NEUT-2034CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC, CyTOF, Neut
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- Human Anti-TLR2 Recombinant Antibody (NEUT-2033CQ) (NEUT-2033CQ)
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- Species Reactivity: Human
- Type: Human IgA2
- Application: Neut, FC
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- Mouse Anti-Tlr2 Recombinant Antibody (NEUT-2032CQ) (NEUT-2032CQ)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: Neut
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- Mouse Anti-TLR2 Recombinant Antibody (clone TL2.1) (NEUT-2031CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: FC, IP, Block, IHC, WB
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- Human Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-269CQ-F(E)) (TAB-269CQ-F(E))
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- Species Reactivity: Human, Mouse
- Type: Humanized Fab
- Application: ELISA, FC, WB, IP
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- Human Anti-TLR2 Recombinant Antibody (TAB-269CQ) (TAB-269CQ)
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- Species Reactivity: Human, Mouse
- Type: Humanized IgG1, κ
- Application: ELISA, FC, FuncS, IP, Inhib
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- Human Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-269CQ-S(P)) (TAB-269CQ-S(P))
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- Species Reactivity: Human, Mouse
- Type: Humanized scFv
- Application: ELISA, FC, WB, IP
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- Human Anti-TLR2 Recombinant Antibody (HPAB-0052-YC) (HPAB-0052-YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: Neut
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- Mouse Anti-TLR2 Recombinant Antibody (VS3-CJ155) (VS3-CJ155)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB
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- Mouse Anti-TLR2 Recombinant Antibody (clone T2.5) (MOR-0004-FY)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: FC, FuncS, IA, IF, IP
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- Rabbit Anti-TLR2 Antibody (MOB-0271MC)
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- Species Reactivity: Reacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Horse, Dog, Chimpanzee, Cynomolgus Monkey, Rhesus monkey, Gorilla, Chinese Hamster - Application: WB
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- Species Reactivity: Reacts with: Human
- Rabbit Anti-TLR2 Recombinant Antibody (clone JM22-41) (MRO-1501-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Human Anti-TLR2 Recombinant Antibody (clone Tomaralimab) (VS-0723-WK9)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG4
- Application: FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, FC, IF, IHC, FuncS
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- Human Anti-TLR2 Recombinant Antibody; scFv Fragment (HPAB-0052-YC-S(P)) (HPAB-0052-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Neut
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- Human Anti-TLR2 Recombinant Antibody; Fab Fragment (HPAB-0052-YC-F(E)) (HPAB-0052-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Neut
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- Mouse Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-268CQ-S(P)) (TAB-268CQ-S(P))
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- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: ELISA, FC, WB, IP
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- Mouse Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-268CQ-F(E)) (TAB-268CQ-F(E))
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- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: ELISA, FC, WB, IP
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- Mouse Anti-TLR2 Recombinant Antibody (TAB-268CQ) (TAB-268CQ)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: FC, IHC, IF, WB
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- CytoStream™ Mouse Anti-TLR2 Recombinant Antibody (clone 11G7) (VS-0225-XY212)
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- Species Reactivity: Human
- Type: Mouse IgG1, kappa
- Application: FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IP
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- Chicken Anti-TLR2 Polyclonal IgY (BRD-0588MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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- Recombinant Anti-TLR2 Intrabody [Tat] (IAB-B030(T))
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- Type: scFv-Tat
- Application: IF, FC, WB, FuncS
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- Recombinant Anti-TLR2 Intrabody [+36 GFP] (IAB-B030(G))
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- Type: scFv-(+36GFP)
- Application: ELISA, WB, ICC, FuncS
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- Recombinant Anti-TLR2 Intrabody [(D-Arg)9] (IAB-B030(A))
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- Type: scFv-(D-Arg)9
- Application: ICC, Neut, FuncS
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For Research Use Only. Not For Clinical Use.
TLR2 is a key component of the innate immune system. It is widely expressed on immune cells including monocytes, macrophages, and dendritic cells. TLR2 can form heterodimers with TLR1 or TLR6. This receptor complex is capable of recognizing a broad range of PAMPs from bacteria, fungi, and parasites. For example, TLR2 - TLR1 detects tri - acylated lipopeptides, while TLR2 - TLR6 binds di - acylated lipopeptides. Once activated, TLR2 - mediated signaling activates transcription factors like NF - κB, resulting in the production of cytokines and chemokines that are important for the early defense against infections.
Protein class
CD markers, Enzymes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Kupffer cells, Macrophages, Alveolar cells type 2, monocytes, Langerhans cells, Microglial cells)
Immune cell specificity
Group enriched (neutrophil, classical monocyte, intermediate monocyte, non-classical monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (HL-60, HSkMC, hTCEpi, NB-4, RPTEC TERT1, RT4, THP-1, U-937)
Interaction
Interacts with LY96, TLR1 and TLR6 (via extracellular domain) (PubMed:17889651). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with TICAM1 (PubMed:12471095). Interacts with CNPY3 (By similarity). Interacts with ATG16L1 (PubMed:23376921). Interacts with PPP1R11 (By similarity). Interacts with TICAM2 (PubMed:25385819). (Microbial infection) Interacts with M. tuberculosis EsxA. (Microbial infection) Interacts with M. bovis MPB83. (Microbial infection) Interacts with Staphylococcus aureus protein SSL5.
Molecular function
Hydrolase, Receptor
More Types Infomation
Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis