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TLR2

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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.

Type:
scFv-(D-Arg)9
Application:
ICC, Neut, FuncS
Type:
scFv-(+36GFP)
Application:
ELISA, WB, ICC, FuncS
Type:
scFv-Tat
Application:
IF, FC, WB, FuncS
Species Reactivity:
Human, Mouse
Application:
ELISA, FC, WB, IP
Species Reactivity:
Human, Mouse
Type:
Humanized antibody
Application:
ELISA, FC, WB, IP
Species Reactivity:
Human
Type:
IgG2a, κ
Application:
FC, IP, BL, IHC, WB
Species Reactivity:
Mouse
Type:
IgG2a
Application:
Neut
Species Reactivity:
Human
Type:
IgA2
Application:
Neut, FC
Species Reactivity:
Human
Type:
IgG2b
Application:
FC, CyTOF, Neut
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB, ICC, IP
Species Reactivity:
Human, Mouse
Application:
ELISA, FC, WB, IP
Species Reactivity:
Human, Mouse
Type:
Humanized antibody
Application:
ELISA, FC, WB, IP
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ELISA, FC, IP
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Species Reactivity:
Human, Mouse
Application:
ELISA, FC, WB, IP
Species Reactivity:
Human, Mouse
Type:
Humanized antibody
Application:
ELISA, FC, WB, IP
Species Reactivity:
Human, Mouse, Rat
Type:
Chicken antibody
Application:
WB
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized IgG
Application:
Neut
Derivation:
Humanized
Species Reactivity:
Human
Type:
Humanized Fab
Application:
Neut
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, IHC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
FC, WB, FuncS
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