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    TLR2

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    Anti-TLR2 Products

    • Rabbit Anti-TLR2 Antibody (MOB-0271MC)
      • Species Reactivity: Reacts with: Human
        Predicted to work with: Mouse, Rat, Sheep, Horse, Dog, Chimpanzee, Cynomolgus Monkey, Rhesus monkey, Gorilla, Chinese Hamster
      • Application: WB
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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Protein class

    CD markers, Enzymes, FDA approved drug targets, Human disease related genes, Transporters

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Kupffer cells, Macrophages, Alveolar cells type 2, monocytes, Langerhans cells, Microglial cells)

    Immune cell specificity

    Group enriched (neutrophil, classical monocyte, intermediate monocyte, non-classical monocyte, myeloid DC)

    Cell line specificity

    Cell line enhanced (HL-60, HSkMC, hTCEpi, NB-4, RPTEC TERT1, RT4, THP-1, U-937)

    Interaction

    Interacts with LY96, TLR1 and TLR6 (via extracellular domain) (PubMed:17889651). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with TICAM1 (PubMed:12471095). Interacts with CNPY3 (By similarity). Interacts with ATG16L1 (PubMed:23376921). Interacts with PPP1R11 (By similarity). Interacts with TICAM2 (PubMed:25385819). (Microbial infection) Interacts with M. tuberculosis EsxA. (Microbial infection) Interacts with M. bovis MPB83. (Microbial infection) Interacts with Staphylococcus aureus protein SSL5.

    Molecular function

    Hydrolase, Receptor

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    Related Signaling Pathways
    NLR Signaling Pathway NLR Signaling Pathway
    TLR Signaling Pathway TLR Signaling Pathway
    Related Diseases
    Rheumatoid Arthritis Rheumatoid Arthritis
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