Mouse Anti-TLR2 Recombinant Antibody (clone TL2.1)
CAT#: NEUT-2031CQ
This antibody is a mouse monoclonal antibody that binds specifically to TLR2, and it can neutralize the bioactivity of TLR2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60231/1551_D10_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HL-60, HSkMC, hTCEpi, NB-4, RPTEC TERT1, RT4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137462-TLR2
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Specifications
- Immunogen
- Human TLR2-transfected CHO cells
- Host Species
- Mouse
- Type
- Mouse IgG2a, κ
- Specificity
- Human TLR2
- Species Reactivity
- Human
- Clone
- TL2.1
- Applications
- FC, IP, Block, IHC, WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Potent Neutralizing Antibody
This mouse monoclonal antibody (clone TL2.1) is highly effective at neutralizing TLR2 bioactivity. We used it in our innate immunity studies to block pathogen recognition pathways, and the results were significant and reproducible across multiple experiments.
Excellent Flow Cytometry Tool
We rely on this antibody for Flow Cytometry analysis of peripheral blood leukocytes. It binds specifically to TLR2 and provides distinct staining. The affinity purification ensures low background, which is critical for our accurate phenotyping of immune cells.
Q&As
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Is this antibody capable of neutralizing TLR2?
A: Yes, the clone TL2.1 is a mouse monoclonal antibody that binds specifically to TLR2 and is capable of neutralizing its bioactivity. We have also validated it for FC, IP, Block, IHC, and WB applications.
-
What is the immunogen and purity of this antibody?
A: This antibody was raised against Human TLR2-transfected CHO cells. It is a Mouse IgG2a, κ antibody. The product is affinity purified and typically exceeds 95% purity as determined by SDS-PAGE analysis.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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