Human Anti-TLR2 scFv-Fc Chimera (VS-0425-FY29)
CAT#: VS-0425-FY29
The anti-TLR2 scFv-Fc antibody is a monoclonal antibody that specifically binds to TLR2, a pattern recognition receptor involved in innate immune responses. In Myelodysplastic Syndromes (MDS), abnormal expression of TLR2 may be associated with disease progression. Therefore, the anti-TLR2 scFv-Fc antibody has potential applications in MDS research, potentially useful for studying the role of TLR2 in MDS and as a potential therapeutic target.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60231/1551_D10_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HL-60, HSkMC, hTCEpi, NB-4, RPTEC TERT1, RT4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137462-TLR2
❮
❯
Specifications
- Immunogen
- Human TLR2/CD282.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human TLR2
- Species Reactivity
- Human, Mouse, Monkey
- Applications
- Flow Cytometry, Inhibition, ELISA
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 1 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Toll Like Receptor 2; Toll/Interleukin-1 Receptor-Like Protein 4; Toll-Like Receptor 2; TIL4; CD282 Antigen; CD282
- Gene ID
- 7097
- UniProt ID
- O60603
- Long Name
- Toll Like Receptor 2
- Cellular Localization
- Cytoplasmic vesicle, Membrane
- Function
- The TLR2 gene encodes Toll-like receptor 2 (TLR2), a key pattern recognition receptor of the innate immune system. Located on the cell surface, TLR2 detects a diverse range of pathogen-associated molecular patterns (PAMPs) from bacteria, fungi, viruses, and parasites. These PAMPs include lipoproteins, lipoteichoic acid, and zymosan.
TLR2 typically functions as a heterodimer with either TLR1 or TLR6 to recognize specific ligands. Upon ligand binding, TLR2 initiates intracellular signaling cascades through adaptor proteins like MyD88, leading to the activation of transcription factors such as NF-κB. This activation results in the production of pro-inflammatory cytokines, chemokines, and other immune mediators, playing a crucial role in host defense against infection.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY29. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TLR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B030(A) | Recombinant Anti-TLR2 Intrabody [(D-Arg)9] | ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B030(G) | Recombinant Anti-TLR2 Intrabody [+36 GFP] | ELISA, WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B030(T) | Recombinant Anti-TLR2 Intrabody [Tat] | IF, FC, WB, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268CQ | Mouse Anti-TLR2 Recombinant Antibody (TAB-268CQ) | FC, IHC, IF, WB | Mouse IgG1, κ |
| TAB-268CQ-S(P) | Mouse Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-268CQ-S(P)) | ELISA, FC, WB, IP | Mouse scFv |
| TAB-268CQ-F(E) | Mouse Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-268CQ-F(E)) | ELISA, FC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-269CQ | Human Anti-TLR2 Recombinant Antibody (TAB-269CQ) | ELISA, FC, FuncS, IP, Inhib | Humanized IgG1, κ |
| TAB-269CQ-S(P) | Human Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-269CQ-S(P)) | ELISA, FC, WB, IP | Humanized scFv |
| TAB-269CQ-F(E) | Human Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-269CQ-F(E)) | ELISA, FC, WB, IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0588MZ | Chicken Anti-TLR2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2031CQ | Mouse Anti-TLR2 Recombinant Antibody (clone TL2.1) | FC, IP, Block, IHC, WB | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2032CQ | Mouse Anti-Tlr2 Recombinant Antibody (NEUT-2032CQ) | Neut | Mouse IgG2a |
| NEUT-2033CQ | Human Anti-TLR2 Recombinant Antibody (NEUT-2033CQ) | Neut, FC | Human IgA2 |
| NEUT-2034CQ | Mouse Anti-TLR2 Recombinant Antibody (clone CBL627) | FC, CyTOF, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3585 | Rabbit Anti-TLR2 Recombinant Antibody (clone DS3585AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-YC-S(P) | Human Anti-TLR2 Recombinant Antibody; scFv Fragment (HPAB-0052-YC-S(P)) | Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-YC-F(E) | Human Anti-TLR2 Recombinant Antibody; Fab Fragment (HPAB-0052-YC-F(E)) | Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1501-CN | Rabbit Anti-TLR2 Recombinant Antibody (clone JM22-41) | WB, IF, IHC, FC | Rabbit IgG |
| FN-140CQ | Human Anti-TLR2 Recombinant Antibody (clone CBL-1309) | FuncS, Block | Human IgG1 |
| FN-171CQ | Rat Anti-Tlr2 Recombinant Antibody (clone 6C2) | FC, FuncS, IF, Neut | Rat IgG2b, κ |
| VS3-CJ24 | Mouse Anti-TLR2 Recombinant Antibody (VS3-CJ24) | WB, ELISA | Mouse IgG |
| VS3-FY1457 | Recombinant Rabbit Anti-Tlr2 Antibody (clone R06-8B6) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY254 | AbPlus™ Anti-TLR2 Magnetic Beads (VS-0424-XY254) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY212 | CytoStream™ Mouse Anti-TLR2 Recombinant Antibody (clone 11G7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC654 | Recombinant Anti-TLR2 Vesicular Antibody, EV Displayed (VS-0425-YC654) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7301 | Anti-TLR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7302 | Anti-Human TLR2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, Neut, IF, IP, FC, FuncS
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: Inhib, FC, WB
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
