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Anti-IL4R Recombinant Antibody Products

AbPlus Recombinant Antibody Products Functional Antibody Products Formats

Anti-IL4R Recombinant Antibody Products

  • IL4-PE immunotoxin (AGTO-L079E)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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  • IL4-DT immunotoxin (AGTO-L079D)
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay
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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides high-grade, comprehensive recombinant antibodies targeting IL4R for biomedical researchers or institutions.

IL4R: A Significant Target of Cancer Disease

IL-4R (interleukin-4 receptor) is a receptor of IL-4, which forms functional receptors in cancer cells. IL4R is highly expressed in various human cancer cells after radiation treatment. Previous research demonstrated that IL4R regulates HCC (hepatocellular carcinoma) cell survival and metastasis, and monitors the activity of the JAK1/STAT6 signaling pathways. IL-4 and IL4R not only play key roles in cancer stem cells but also provide hinge targets to eradicate these cells. Then IL-4R may be a unique therapeutic target for various cancer diseases.

Alternative Names

IL4R; interleukin 4 receptor; CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL4R nirs variant 1; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain

Background

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Protein class

Cancer-related genes, CD markers, FDA approved drug targets, Human disease related genes, Plasma proteins, Transporters

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (granulocytes, B-cells)

Immune cell specificity

Immune cell enhanced (naive B-cell)

Cell line specificity

Cell line enhanced (Daudi, HBEC3-KT, HDLM-2, U-698)

Interaction

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity). Interacts with JAK3 (PubMed:7538655). Interacts with CLM1 (By similarity).

Molecular function

Receptor

More Types Infomation

Anti-IL4R Recombinant Antibody Products

The high-quality anti-IL4R recombinant antibody products are provided to accelerate research and discovery of target-related drugs.

Cat. No. Product Name Target Species Host Species Applications
TAB-0004CL Anti-Human IL4R Recombinant Antibody (12B5) Human Human Inhib; RIA; ELISA; Block
HPAB-0071-WJ Human Anti-IL4R Recombinant Antibody (HPAB-0071-WJ) Human Human ELISA; WB
TAB-668LC Anti-human IL4R Recombinant Antibody Cynomolgus monkey Human ELISA; FC
TAB-433CL Human Anti-IL4R Recombinant Antibody Human Human FuncS
HPAB-0291-YC Human Anti-IL4R Recombinant Antibody (clone Antibody 1) Human; Cynomolgus monkey Human HTRF; FuncS

Creative Quality Control

To satisfy our customers' needs in antibody quality, a stringent quality management system has been established to ensure our product quality and help customers better engage in research work.

Fig.1 SDS-PAGE analysis of HPAB-0291-YC. (Creative Biolabs Original)Fig.1 SDS-PAGE analysis of anti-IL4R antibody (Cat#
HPAB-0291-YC, Creative Biolabs).

Fig.2 SEC-HPLC analysis of HPAB-0291-YC. (Creative Biolabs Original)Fig.2 SEC-HPLC analysis of anti-IL4R antibody (Cat#
HPAB-0291-YC, Creative Biolabs).

Fig.3 ELISA analysis of TAB-433CL. (Creative Biolabs Original)Fig.3 ELISA analysis of anti-IL4R antibody (Cat#
TAB-433CL, Creative Biolabs).

Fig.4 WB analysis of TAB-433CL. (Creative Biolabs Original)Fig.4 WB analysis of anti-IL4R antibody (Cat#
TAB-433CL, Creative Biolabs).

Fig.5 DB analysis of TAB-433CL. (Creative Biolabs Original)Fig.5 DB analysis of anti-IL4R antibody (Cat#
TAB-433CL, Creative Biolabs).

Customer Reviews

Excellent
La**y
Human Anti-IL4R Recombinant Antibody (clone Antibody 1) (Cat#: HPAB-0291-YC)
The anti-IL4R recombinant human antibody was used to test the binding affinity with IL4-Receptor in cancer cells. According to the proportion and method recommended by the company's technicians, the experiment obtained good results, which proved that the antibody had a good binding effect with IL4R.
27/Jan/2024
Excellent
Jo**s
Anti-human IL4R Recombinant Antibody (Cat#: TAB-668LC)
I purchased the Anti-Human IL4R Recombinant Antibody (TAB-668CL) to detect the expression and distribution of IL4R in various cell types. This antibody has been extremely useful in my research. It enables me to accurately identify and quantify the IL4R, helping me understand the role of this receptor in immune responses and related diseases. The high specificity and sensitivity of this antibody ensure the reliability of my experimental results, and it has significantly contributed to the advancement of my study.
19/Feb/2024
Excellent
Em**y
Anti-Human IL4R Recombinant Antibody (12B5) (Cat#: TAB-0004CL)
The Anti-human IL4R Recombinant Antibody (TAB-0004LC) has been truly excellent. I'm extremely impressed with its high specificity, which guarantees precise and accurate results in my experiments. Not only that, but its stability is also remarkable, making it very convenient and reliable to handle. I'm genuinely pleased with this antibody as it binds strongly to the IL4R and has significantly facilitated my research, proving to be an outstanding and trustworthy tool.
5/Aug/2023

Anti-IL4R Recombinant Antibody Production

We have many years of process optimization experience in the expression vectors, screening transfected cell lines, and purifying antibodies. We provide high-class services from gene synthesis to antibody production for biomedical researchers.

Featured Anti-IL4R Recombinant Antibody Production Platforms Fig.6 Milligram-scale anti-IL4R recombinant antibody production. (Creative Biolabs Original)
Fig.6 Milligram-scale recombinant antibody production.

Fig.7 Gram-scale anti-IL4R recombinant antibody production. (Creative Biolabs Original)Fig.7 Gram-scale recombinant antibody production

Anti-IL4R Recombinant Antibody Modalities

Creative Biolabs is dedicated to providing researchers with high-quality recombinant antibodies in different formats for meeting our customers' requirements. The antibody format includes but is not limited to full length, Fab, scFv, scFv-Fc, etc.

Fig.8 Full Length Anti-IL4R Recombinant Antibody Production and Modalities. (Creative Biolabs Original) Fig.8 Full-Length Anti-IL4R Recombinant Antibody Production and Modalities

IL4R-Targeted Drug Information

Table 1. Therapeutic approaches targeting IL4R in clinical development.

Research phase Company Classification Indications Details
Launched - 2022 Regeneron Human Monoclonal Antibody Asthma; Atopic dermatitis; Chronic rhinosinusitis; Esophagitis; Chronic obstructive pulmonary disease (COPD) D**umab is a human monoclonal antibody used in the treatment of Asthma and Atopic dermatitis.
Phase III KeyMed Biosciences Biologics Asthma; Atopic dermatitis; Chronic rhinosinusitis with nasal polyps S***okibart  is an antibody under research and might be used for the treatment of Asthma and Atopic dermatitis.
Phase II Akeso Biopharma Monoclonal Antibody Atopic dermatitis A*-120 is a monoclonal  antibody being researched and could potentially be utilized for the treatment of Atopic dermatitis.
Phase II Amgen Human Monoclonal Antibody Asthma A**-317  is a human monoclonal antibody under research and might be used for the treatment of Asthma.
Phase II Dragon Boat Biopharmaceutical Humanized Monoclonal Antibody Asthma; Atopic dermatitis B*-005  is an antibody under research and might be used for the treatment of Asthma and Atopic dermatitis.
Phase II Medicenna Therapeutics Fusion Proteins
Polypeptides, from 41 AA
Toxins 		Glioblastoma multiforme; Cancer B***ofusp is a fusion proteins polypeptides under research and might be used for the treatment of glioblastoma multiforme and cancer.
Phase II Genrix (Shanghai) Biopharmaceutical Monoclonal Antibody Chronic rhinosinusitis G*-1802 is a monoclonal  antibody being researched and could potentially be utilized for the treatment of Chronic rhinosinusitis.
Phase II Altair Therapeutics Biologic Asthma A**-645 is a biologic being researched and could potentially be utilized for the treatment of Asthma.
Phase II Aerovance Peptides Asthma; Eczema P**ki*ra is a peptides under research and might be used for the treatment of Asthma and Eczema.
Phase II Connect Biopharma Human Monoclonal Antibody Asthma; Atopic dermatitis R**mi**bart is a human monoclonal antibody under research and might be used for the treatment of Asthma and Atopic dermatitis.
Phase II Chia Tai Tianqing Pharmaceutical Human Monoclonal Antibody Atopic dermatitis T*H-2722 is a human monoclonal antibody being researched and could potentially be utilized for the treatment of Atopic dermatitis.
Phase I Apogee Therapeutics Monoclonal Antibody Asthma; Chronic obstructive pulmonary disease (COPD) AP*-808 is a monoclonal antibody being researched and could potentially be utilized for the treatment of Asthma and Chronic obstructive pulmonary disease (COPD).
Phase I Shanghai Novamab Single-Domain Antibody Asthma *Q-036  is a single-domain antibody under research and might be used for the treatment of Asthma.
Phase I Numab Therapeutics Multispecific Antibody Atopic dermatitis N*-26 is an multispecific antibody under research and might be used for the treatment of Atopic dermatitis.
Preclinical Serodus Peptides Diabetic neuropathy P*-8 is a peptides being researched and could potentially be utilized for the treatment of Diabetic neuropathy.

If you need more information regarding anti-IL4R recombinant antibody products, do not hesitate to contact us. We anticipate developing a mutually beneficial collaboration with you.

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