Anti-JAK1 Recombinant Antibody Products

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Anti-JAK1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in developing state-of-the-art recombinant antibodies for JAK1 research, serving the global scientific community. By leveraging innovative techniques and stringent quality assurance protocols, our antibody products deliver exceptional performance, featuring precise targeting, enhanced detection capabilities, and consistent results. These antibodies are versatile tools for diverse applications, such as pharmaceutical screening, disease mechanism exploration, and novel therapy development. Dedicated to driving scientific progress, we strive to offer innovative research solutions that meet the evolving needs of biomedical research.

JAK1: A Significant Target of Cancer and Inflammatory Disease

JAK1 (Janus kinase 1) is a crucial member of the Janus kinase family, playing a key role in intracellular signal transduction for various cytokines and growth factors. It is essential for activating the JAK-STAT signaling pathway, which regulates immune responses, inflammation, and hematopoiesis. JAK1 is involved in mediating signals from type I and type II cytokine receptors, impacting immune cell function and inflammatory diseases. Dysregulation of JAK1 has been linked to autoimmune disorders, cancers, and inflammatory conditions, making it an important therapeutic target for drug development in immunology and oncology.

Alternative Names

JTK3; AIIDE; JAK1A; JAK1B

Background

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.

Anti-JAK1 Recombinant Antibody Products

Premium anti-JAK1 recombinant antibodies are available to support and enhance research efforts, facilitating the development of novel target-specific drugs. These high-performance antibodies play a vital role in advancing biomedical studies and accelerating breakthroughs in therapeutic discovery.

Creative Quality Control

To meet customer expectations for superior antibody quality, we have implemented a rigorous quality management system. This ensures the reliability and consistency of our products, enabling researchers to conduct their studies with greater confidence and efficiency while achieving more accurate and reproducible results.

Customer Reviews

Excellent

Za**ry
Recombinant Rabbit Anti-JAK1 Monoclonal Antibody (JM75-03) (Cat#: MRO-0879-CN)

The Recombinant Rabbit Anti-JAK1 Monoclonal Antibody is applicable for detecting JAK1 in WB, IHC, and FC. It accurately identifies JAK1 protein levels, aiding studies on signal pathways and diseases. Its recombinant production ensures batch consistency and low background noise, suitable for basic and translational research.

14/Jan/2024

Excellent

Pat**ck
Mouse Anti-JAK1 Recombinant Antibody (clone 7G6) (Cat#: MOB-0063F)

The Mouse Anti-JAK1 Recombinant Antibody effectively detects JAK1 expression. Applied in IHC and IF, it precisely localizes JAK1 in tissues and cells. With high specificity and sensitivity, it supports research on JAK1 - related signaling and disease mechanisms.

16May/2023

Excellent

Au**ra
Mouse Anti-JAK1 Recombinant Antibody (clone 5B5) (Cat#: MOB-2481z)

The Mouse Anti-JAK1 Recombinant Antibody reliably detects JAK1 protein expression, applicable in multiple assays like WB, ICC, IF, IHC, and IP. Ideal for studying JAK1 - related signaling, its high specificity and reproducibility ensure accurate results in immunology and molecular biology research.

18/Jun/2023

Anti-JAK1 Recombinant Antibody Production

With extensive experience in process optimization, we specialize in expression vectors, screening transfected cell lines, and antibody purification. Our comprehensive services cover the entire process, from gene synthesis to antibody production, offering high-quality support to biomedical researchers. We are committed to delivering exceptional solutions that streamline research and accelerate the development of innovative therapies.

Featured Anti-JAK1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

Anti-JAK1 Recombinant Antibody Modalities

Creative Biolabs is committed to offering researchers high-quality recombinant antibodies in various formats to meet diverse needs. Our antibody formats include, but are not limited to, full-length, Fab, scFv, scFv-Fc, and more, ensuring flexibility and suitability for a wide range of applications in scientific research.

Fig.4 Full Length Anti-JAK1 Recombinant Antibody Production and Modalities.

Drug Information Targeting JAK1

Table 1. Therapeutic approaches targeting JAK1 in clinical development.

For additional details about our anti-JAK1 recombinant antibody products, please feel free to reach out to us. We are eager to provide you with the information you need and explore opportunities for a productive and mutually beneficial partnership. Our team is dedicated to supporting your research and ensuring your success in developing innovative solutions.

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