Afuco™ Anti-Human MADCAM1 ADCC Recombinant Antibody (PF-00547659), ADCC Enhanced (CAT#: AFC-489CL)
Anti-MADCAM1 ADCC Enhanced Antibody (PF-00547659) is an ADCC enhanced antibody produced by our Afuco™ platform. PF-00547659 is an anti-human MAdCAM monoclonal antibody which has potential utility in the treatment of inflammatory conditions by blocking tissue homing of activated α4β7+ leukocytes. The characterization of a rodent cross-reacting antibody as a surrogate for PF-00547659 in the search for potential pharmacological biomarkers and the determination of efficacious doses was effective in addressing the restricted orthologous cross-reactivity of PF-00547659 and the challenges this poses with respect to efficacy and safety testing.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human appendix
(Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77998/169642_A_3_2_selected.jpg
(Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/77998/169642_A_3_2_selected.jpg
Figure 2 Appendix
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_2_2_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_2_2_val_selected.jpg
Figure 3 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_8_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes -)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_7_4.jpg
(Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_7_4.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75699/159464_A_6_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (HEK93, Hep G2, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099866-MADCAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099866-MADCAM1
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Crohn's Disease; Inflammatory Diseases; Ulcerative Colitis
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MADCAM1; mucosal vascular addressin cell adhesion molecule 1; MACAM1; mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1
- Gene ID
- 8174
- UniProt ID
- Q13477
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1935z | Mouse Anti-MADCAM1 Recombinant Antibody (MOB-1935z) | IHC, IF, ELISA | Mouse IgG2a |
| MOB-1116CT | Recombinant Mouse anti-Human MADCAM1 Monoclonal antibody (28G6) | FC | |
| HPAB-0040-DJB | Human Anti-MADCAM1 Recombinant Antibody (HPAB-0040-DJB) | ELISA | Human IgG2, κ |
| HPAB-0041-DJB | Human Anti-MADCAM1 Recombinant Antibody (HPAB-0041-DJB) | ELISA | Human IgG4, κ |
| HPAB-0042-DJB | Human Anti-MADCAM1 Recombinant Antibody (HPAB-0042-DJB) | ELISA | Human IgG4, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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