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    SCLC1 & CD3

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    Anti-SCLC1 & CD3 Products

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
    Diseases associated with SCLC1 include Small Cell Cancer Of The Lung. SCLC1 has the protein tyrosine phosphatase activity and functions in the T cell receptor signaling pathway.
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