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VEGF & VEGF-B

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Anti-VEGF & VEGF-B Products

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For Research Use Only. Not For Clinical Use.


Background

VEGF is a signaling protein that stimulates angiogenesis (the formation of new blood vessels). It plays a crucial role in normal development and in diseases like cancer and macular degeneration.
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
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